CAR-T Investigation: FDA Leaders Detail Decision on Cancer Risk Warning
The FDA has identified more cases of secondary T-cell malignancies following treatment with chimeric antigen receptor (CAR) T-cell therapies, cases that led the agency to demand new boxed warnings on approved agents in the class. With about 27,000 doses of the six B-cell maturation antigen (BCMA)- or CD19-directed CAR-T products having been administered in the […]
Vaccinated Blood Cancer Patients Still at Risk for Severe COVID-19
Patients with hematologic malignancies who had breakthrough COVID-19 infections still had high risk for severe or critical disease, according to a registry-based study. Out of 113 reported cases of SARS-CoV-2 infection post-vaccination in people with blood cancers, 79 (60.4%) experienced severe or critical disease, with 75 requiring hospitalization, reported Livio Pagano, MD, of the Università […]