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Blended antioxidant supplement improves cognition and memory in aged mice

Cell damage from oxidative stress is a major underlying cause of age-related cognitive and muscle strength decline. Antioxidants can reduce oxidative stress and prevent age-related health decline. A new study has found that mice administered with a blended antioxidant supplement show significant improvements in spatial cognition, short-term memory, and mitigated age-related muscle decline. The study […]

Maternal obesity may promote liver cancer

Obesity, which could reach 50% of the population in certain developed countries by 2030, is a major public health concern. It not only affects the health of those who suffer from it, but could also have serious consequences for their offspring. Scientists at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) have […]

Vitamin D supplements do not prevent bone fractures in children

A major clinical trial led by Queen Mary University of London and the Harvard T.H. Chan School of Public Health has found that vitamin D supplements do not increase bone strength or prevent bone fractures in children with vitamin D deficiency. The findings challenge widely held perceptions relating to the effects of vitamin D on […]

Colchicine Stumbles for Protecting the Heart From Thoracic Surgery

AMSTERDAM — Anti-inflammatory colchicine (Lodoco) given perioperatively around major non-cardiac thoracic surgery did not cut atrial fibrillation (Afib) or myocardial injury complications, the COP-AF trial showed, although with some positive post hoc endpoints. Clinically important Afib occurred in 6.4% of colchicine-treated patients and 7.5% of placebo recipients (HR 0.85, 95% CI 0.65-1.10, P=0.22), David Conen, […]

Vitamin D for Cardiovascular Prevention Runs Into Another Wall

Monthly super-sized vitamin D supplements failed to significantly reduce major cardiovascular events in older adults, the Australian D-Health Trial found. Over up to 5 years of treatment, incident myocardial infarction (MI), stroke, and coronary revascularization turned up in 6% of the vitamin D group and 6.6% of the placebo group (HR 0.91, 95% CI 0.81-1.01), […]

Novel Triple Agonist Nabs Biggest Weight Loss Yet in Obesity Trial

SAN DIEGO — An investigational triple-hormone receptor agonist yielded major weight loss in people with obesity, a phase II trial showed. By 24 weeks, patients on any of the four doses of once-weekly injectable retatrutide lost a significantly greater amount of weight than those on placebo — achieving the trial’s primary endpoint — reported Ania […]

No Increase in Major Cardiac Events With Testosterone-Replacement Therapy

CHICAGO — Testosterone-replacement therapy was noninferior to placebo in the occurrence of major adverse cardiac events among men with hypogonadism and established or high risk for cardiovascular disease, the randomized TRAVERSE trial showed. At a mean follow-up of 33 months, the primary cardiovascular endpoint — first occurrence of any component of a composite of death […]

Ketamine Matches ‘Gold Standard’ in Major Depression Trial

SAN FRANCISCO — When it came to improving treatment-resistant major depression in outpatients without psychotic features, ketamine worked just as well as electroconvulsive therapy (ECT), the ELEKT-D randomized trial found. Following a 3-week treatment period, 55.4% of the patients in the ketamine group and 41.2% of those in the ECT group had a treatment response, […]

Childhood Cancer Survivors Have Increased Rates of Late, Major Surgeries

Childhood cancer survivors have increased rates of undergoing late, major surgical procedures 5 or more years after diagnosis, according to data from the Childhood Cancer Survivor Study. Among more than 25,000 survivors diagnosed with cancer from 1970 to 1999 when they were under age 21, the likelihood of having subsequent major surgery was 80% higher […]

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