Pediatric Sarcoma Patients Face Late Amputation Risk Decades Later
BALTIMORE — Pediatric patients who underwent limb salvage surgery (LSS) for lower extremity sarcomas had a substantial risk of undergoing late amputation, a researcher reported. In a retrospective analysis of data from the Childhood Cancer Survivor Study (CCSS), the cumulative incidence of late amputation at 20 years after LSS was almost one out of every […]
A Cup of Joe to Thwart Liver Fibrosis? How About Four
High coffee consumption was linked to a lower risk for elevated liver stiffness, though no such association was seen with steatosis, researchers found in a cross-sectional study. In a dietary analysis involving over 4,500 adults, drinking more than 3 cups of coffee (versus none) was associated with a 0.9 kPa reduction (95% CI -1.6 to […]
Statin Cholesterol Drugs May Help Fight Ulcerative Colitis — MedicineNet Health News
Latest Digestion News THURSDAY, Sept. 16, 2021 Millions of people take statins to lower their cholesterol, and new research suggests these drugs may also ease ulcerative colitis. An inflammatory bowel disease with no real cure, ulcerative colitis causes sore spots on the lining of the colon that can lead to rectal bleeding, diarrhea […]
Liver Toxicity in Gene Therapy Trials Could Merit Stricter Entry Criteria
An FDA advisory committee offered up lower vector doses, stricter exclusion criteria, and long-term animal studies to grapple with liver toxicities associated with adeno-associated virus (AAV) vector-based gene therapies. During the second of four sessions on AAV safety, the Cellular, Tissue, and Gene Therapies Advisory Committee (CTGTAC) weighed evidence of hepatotoxicity — ranging from liver […]
Maybe Avoid These Specialists for Your Next Colonoscopy
Colonoscopies performed by surgeons and other endoscopists were associated with lower adenoma detection rates compared to those done by gastroenterologists, according to a meta-analysis. In a systematic review of 36 studies, adenoma detection rates during colonoscopy were 19% lower with surgeons (OR 0.81, 95% CI 0.74-0.88) and 9% lower with family physicians, general practitioners, and […]
Immigrants to Canada may have lower rate of stroke than long-term residents
Immigrants to Canada have a 33% lower rate of stroke than long-term residents, according to a study published in the August 18, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Other studies have shown that immigrants tend to have better health than long-term residents, which is thought to be […]
Do some diabetes drugs reduce the risk of Alzheimer’s? Study finds people taking the drugs have fewer biomarkers, slower cognitive decline
People taking certain drugs to lower blood sugar for type 2 diabetes had less amyloid in the brain, a biomarker of Alzheimer’s disease, when compared to both people with type 2 diabetes not taking the drugs and people without diabetes. The new study, published in the August 11, 2021, online issue of Neurology, the medical […]
Black Prostate Cancer Patients Less Likely to Go Under the Knife During Pandemic
The odds of undergoing surgery for prostate cancer were significantly lower for Black patients compared with white patients during the initial wave of the COVID-19 pandemic, according to a retrospective cohort study. Just 1% of Black men with untreated nonmetastatic prostate cancer underwent prostatectomy from March to May 2020 compared with 26% of white men, […]
Can Education Tackle Poor Antibiotic Prescribing in Nursing Homes?
An educational intervention to cut inappropriate antibiotic use for suspected urinary tract infections (UTIs) and lower respiratory tract infections among nursing home residents with advanced dementia had a limited impact in a cluster randomized trial. The multicomponent TRAIN-AD intervention reduced such prescribing by 33% per person-year compared with usual care (adjusted marginal rate difference −0.27, […]