Low-Dose Intradermal Mpox Vaccine on Par With Subcutaneous Dosing
Mpox vaccination with a two-shot, low-dose intradermal approach produced similar antibody titers levels compared with the standard subcutaneous dosing regimen, an observational study showed. Two 0.1-mL intradermal doses of the modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine yielded geometric mean titers of immunoglobulin G (IgG) antibodies that neutralize mpox of 88.65 (95% CI 48.09-163.42), compared with […]
Daily Low-Dose Aspirin Upped Incidence of Anemia in Older Adults
Daily low-dose aspirin increased incident anemia among otherwise healthy older adults, a secondary analysis of the randomized ASPREE trial showed. Over a median of 4.7 years, the incidence of anemia was 51.2 events per 1,000 person-years in the aspirin group compared with 42.9 events per 1,000 person-years in the placebo group (HR 1.20, 95% CI […]
Lung Cancer Survival High for Patients With Early, Screen-Detected Tumors
CHICAGO — The diagnosis of early-stage lung cancer with low-dose CT (LDCT) screening led to high rates of lung cancer-specific survival two decades later, according to I-ELCAP data. The 20-year lung cancer-specific survival rate was 80% for the 1,285 I-ELCAP participants diagnosed with early-stage disease, reported Claudia Henschke, MD, PhD, of Mount Sinai Icahn School […]
Study Refutes Heart Health Claims of Dietary Supplements
CHICAGO — For people without heart disease, preventive low-dose statin therapy lowered LDL cholesterol to a degree that dietary supplements and placebo couldn’t match, a randomized trial found. People taking rosuvastatin 5 mg per day for 4 weeks had an average 37.9% reduction in LDL cholesterol, the only group to do better than the placebo […]
Low-Dose Cariprazine for MDD Tied to Anxiety Reduction
NEW ORLEANS — Low-dose cariprazine (Vraylar) was associated with reductions in anxiety for patients with major depressive disorder (MDD), and the potential adjunctive therapy for this population also demonstrated improvements across most individual symptoms of depression, according to two post hoc analyses of a phase III trial. When combined with an antidepressant for MDD patients […]
LDCT Screening Linked to Lower Risk of Brain Mets in Lung Cancer
Patients with primary lung cancer detected with low-dose computed tomography (LDCT) screening have a lower risk of developing brain metastases than patients whose cancer was detected through other methods, researchers found. After adjusting for age at diagnosis, cancer stage, histology, and smoking status, patients whose lung cancer was detected with LDCT screening had a significantly […]