TAVR Chugging Along at 5 Years in SURTAVI Trial
Researchers keeping an eye on the long-term outcomes of people undergoing transcatheter aortic valve replacement (TAVR) reported encouraging results in both clinical and economic terms, according to two reports from the Transcatheter Cardiovascular Therapeutics (TCT) meeting. The 5-year incidence of all-cause mortality or disabling stroke among people in the SURTAVI trial was no different between […]
What Are the Long-Term Side Effects of Rheumatic Fever? Complications
If not promptly treated, rheumatic fever can have long-term side effects such as rheumatic heart disease, which weakens the valves between the heart’s chambers. The majority of rheumatic fever (RF) symptoms go away after a few weeks or months, but recurrence and certain complications are common. Usually, heart and joint ailments are long-term consequences of […]
Meds, surgery may help obesity-related high blood pressure if diet, exercise fall short
Weight-loss medications and surgical procedures show promise for reducing the long-term effects of high blood pressure (also called hypertension) in people who are overweight or have obesity, according to a new American Heart Association scientific statement published today in the Association’s journal Hypertension. A scientific statement is an expert analysis of current research and may […]
Liver Toxicity in Gene Therapy Trials Could Merit Stricter Entry Criteria
An FDA advisory committee offered up lower vector doses, stricter exclusion criteria, and long-term animal studies to grapple with liver toxicities associated with adeno-associated virus (AAV) vector-based gene therapies. During the second of four sessions on AAV safety, the Cellular, Tissue, and Gene Therapies Advisory Committee (CTGTAC) weighed evidence of hepatotoxicity — ranging from liver […]
Indigenous and local communities key to successful nature conservation
Indigenous Peoples and local communities provide the best long-term outcomes for conservation, according to new research from the University of East Anglia (UEA) and partners in France. Lead author, Dr Neil Dawson of UEA’s School of International Development, was part of an international team conducting a systematic review that found conservation success is “the exception […]
Benefits of Adjuvant Radiation in DCIS Persist Out to 15 Years
Adjuvant radiation therapy (RT) for good-risk ductal carcinoma in situ (DCIS) reduced long-term ipsilateral breast recurrence (IBR) by more than 50% compared with observation, results of a large intergroup study showed. RT, following surgery with or without tamoxifen, decreased 15-year IBR from 15.1% with observation to 7.1%. RT also reduced the odds of invasive local […]
Immigrants to Canada may have lower rate of stroke than long-term residents
Immigrants to Canada have a 33% lower rate of stroke than long-term residents, according to a study published in the August 18, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Other studies have shown that immigrants tend to have better health than long-term residents, which is thought to be […]
Breast Cancer Control Similar With Intermittent, Continuous Endocrine Therapy
Intermittent or continuous extended adjuvant endocrine therapy led to virtually identical long-term survival in hormone receptor (HR)-positive breast cancer, according to an updated analysis of a randomized trial. Disease-free survival (DFS) at 7 years was 81.4% with intermittent extended letrozole and 81.5% with continuous treatment. The results mirrored previously reported 5-year DFS, which also did […]
CDC: Lower Vax Rates in Nursing Homes Among Low-Wage Staff
COVID-19 vaccination rates varied widely among healthcare personnel (HCP) who worked in long-term care facilities (LTCFs), with less than half of aides vaccinated, researchers found. In March 2021, the highest vaccination rates were seen in physicians and advanced practice providers (75%), while the lowest rates occurred in aides (45.6%), reported James T. Lee, MD, of […]
8 Lasting Changes Experts Think We’ll See In Kids After This ‘Lost’ Year
The COVID-19 pandemic changed all of our lives, but for developing children, its impact may have more long-term effects. “Every child’s experience of the pandemic is different based on their temperament and their home life,” Jacqueline P. Wight, director of mental health services at DotCom Therapy, told HuffPost. “Many children have experienced mental health challenges, […]