Omega-3 Fatty Acids May Also Help Lung Health
Omega-3 fatty acids may play a protective role in long-term lung health, according to longitudinal and Mendelian randomization analyses. Higher plasma levels of omega-3 fatty acid were associated with attenuated lung function decline in 15,063 patients with repeated measures of forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), reported Patricia […]
Case Builds Against Beta-Blockers Beyond First Year After Heart Attack
The conventional wisdom of giving long-term beta-blockers for secondary prevention after myocardial infarction (MI), in the absence of another clinical indication, was questioned by a large cohort study from Sweden. For survivors who were still on beta-blocker therapy 1 year after heart attack hospitalization and had a normal left ventricular (LV) ejection fraction, the next […]
FDA Mulling Trial Design Issues for Long-Term Opioids in Chronic Pain
To evaluate the long-term efficacy and tolerability of a representative extended-release (ER)/long-acting (LA) opioid in a 12-month placebo-controlled trial, FDA staff are considering an enriched enrollment randomized withdrawal (EERW) study design, they noted in a briefing document ahead of an advisory committee meeting. On Wednesday, the Anesthetic and Analgesic Drug Products Advisory Committee will consider […]
Long-Term Exposure to Extreme Temps Tied to Newborn Lung Function
Long-term exposure to heat and cold from the second trimester to 4 weeks after birth was associated with lung function among female newborns, according to a French population-based cohort study. Specifically, long-term heat and cold exposure were associated with decreased functional residual capacity (FRC) and increased respiratory rate, while only long-term cold exposure was linked […]
Common food dye can trigger inflammatory bowel diseases, animal study suggests: Allura Red (also called FD&C Red 40 and Food Red 17), is a common ingredient in candies, soft drinks, dairy products and some cereals
Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis, says McMaster University’s Waliul Khan. Researchers using experimental animal models of IBD found that continual exposure to Allura Red AC harms gut health and promotes inflammation. The dye directly disrupts gut barrier function […]
Green tea extract may harm liver in people with certain genetic variations
Long-term use of high-dose green tea extract may provide some protection against cancer, cardiovascular disease, obesity and type 2 diabetes, but it also may create liver damage in a small minority of the population. Who is at risk? Research from Rutgers, published in The Journal of Dietary Supplements, provides the first solid clue: two genetic […]
Testosterone Tied to Sustained Weight Loss in Men With Hypogonadism and Obesity
SAN DIEGO — Long-term testosterone therapy was associated with sustained reductions in weight for men with hypogonadism and class III obesity, a researcher reported. In registry data on 76 patients, those who opted to receive testosterone undecanoate experienced a 26% reduction in their body mass index (BMI) over close to a decade of follow-up, reported […]
Maintenance PARP Inhibition Boosts OS in Two Ovarian Cancer Trials
PARIS — Olaparib (Lynparza) maintenance therapy appears to offer a long-term overall survival (OS) benefit for women with ovarian cancer, according to two phase III studies presented at the European Society for Medical Oncology (ESMO) annual congress. At 7 years in the SOLO-1 trial, 67% of patients with advanced BRCA-mutated ovarian cancer treated with the […]
10-Year Follow-Up Confirms Benefit of Chemoradiotherapy in MIBC Patients
Long-term results confirmed that the benefit of adding chemotherapy to radiotherapy was maintained in patients with muscle-invasive bladder cancer (MIBC) in a follow-up to the phase III randomized BC2001 trial. Over a median follow-up of about 10 years, locoregional control was significantly improved by adding 5-fluorouracil and mitomycin C to radiotherapy, with a 5-year recurrence-free […]
Durable Responses, Safety in Atopic Dermatitis Treated With IL-13 Inhibitor
The interleukin (IL)-13 inhibitor tralokinumab (Adbry) for atopic dermatitis provided long-term disease control with a favorable safety profile and improved quality of life (QoL), data from two studies showed. Interim results from a long-term extension study showed that 82.5% of patients had at least 75% improvement in the Eczema Area and Severity Index (EASI-75) after […]