MRI-Guided RT Reduced Acute Toxic Effects in Men With Localized Prostate Cancer
Stereotactic body radiotherapy (SBRT) guided by MRI for localized prostate cancer resulted in fewer toxicities and an improvement in quality of life compared with CT guidance, according to the randomized phase III MIRAGE trial. At 3-month follow-up, incidence of acute grade 2 or higher genitourinary toxic effects was 24.4% with MRI-guided SBRT versus 43.4% with […]
Xtandi During AS Reduced Progression Risk in Early Prostate Cancer
Patients with low- or intermediate-risk localized prostate cancer who received enzalutamide (Xtandi) monotherapy saw a reduced risk of cancer progression, according to a randomized phase II trial. Among 227 patients on active surveillance (AS), treatment with enzalutamide reduced the risk of pathological or therapeutic prostate cancer progression by 46% compared with AS alone (HR 0.54, […]
Testicular Mass Serendipitously Found 12 Years After Prostate Cancer Dx
A 79-year-old man with a 12-year history of clinically localized prostate cancer presented to a hospital with a urethral stricture. He had developed radiation cystitis and low-grade non-invasive urothelial carcinoma of the bladder some time after he received proton therapy following his prostate cancer diagnosis. In the process of prepping the patient for cystoscopic dilation […]
Can Prostate Cancer Patients on AS Delay Surgery at Progression?
Among men with clinically localized prostate cancer who continued active surveillance (AS) after biopsy progression, delaying surgery did not significantly reduce recurrence-free survival (RFS) rates or increase the risk of adverse pathology, researchers reported. In a prospectively followed cohort, men on AS who underwent early radical prostatectomy (RP) had a 3-year RFS rate of 80%, […]
In Early Prostate Cancer, Black Men Do Better With Radiotherapy Than White Men
Black men with localized prostate cancer had better treatment- and disease-specific outcomes than white men when treated with definitive radiotherapy, according to the results of a meta-analysis. Even though Black men were more likely to present with high-risk features, they were less likely to experience biochemical recurrence (subdistribution hazard ratio [sHR] 0.88, 95% CI 0.80-0.96, […]