Linaclotide Eases Abdominal Symptoms in IBS With Constipation
Linaclotide (Linzess) significantly alleviated abdominal symptoms in irritable bowel syndrome (IBS) patients with predominant constipation compared with placebo, researchers found in a randomized study. Using an abdominal score that averaged abdominal bloating, discomfort, and pain on an 11-point scale, the average overall change from baseline was -1.9 for patients treated with linaclotide and -1.2 for […]
First Drug Approved for Kids’ Functional Constipation
The FDA approved linaclotide (Linzess) capsules for treating functional constipation in kids 6 years and up, the agency announced on Monday. Along with data from trials in adults with chronic idiopathic constipation, support for the pediatric approval came from a phase III trial that included 330 children and adolescents ages 6 to 17 years with […]