Scientists identify how dietary restriction slows brain aging and increases lifespan
Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for […]
How fit is your gut microbiome? New research shows duration and not intensity of exercise is most important
Exercise has many benefits — strengthening muscles and bones, preventing disease and extending lifespan. It is also known to change the composition and activity of the trillions of microbes in our guts known as the microbiome. It is well known that the microbiomes of athletes are different from those who are sedentary. This is not […]
A single hormone directs body’s responses to low-protein diet: Mice live longer and lose weight while eating more when FGF21 is present
A single hormone appears to coordinate the lifespan extension produced by a low-protein diet. A new study from Pennington Biomedical Research Center, published in the journal Nature Communications, found that reducing the amount of protein in the diet produced an array of favorable health outcomes, including an extension of lifespan, and that these effects depend […]
Researchers provide a framework to study precision nutrigeroscience
Dietary restriction is arguably the most promising non-genetic method of extending lifespan and healthspan in many model organisms, including mammals. While researchers scramble to develop interventions that would mimic the benefits of dietary restrictions in humans (who generally have a hard time maintaining Spartan diets), the work from the lab of Buck professor Pankaj Kapahi, […]