Specific genetic variant may help prevent obesity
A preclinical study by Weill Cornell Medicine investigators shows that a specific human genetic variant of a receptor that stimulates insulin release may help individuals be more resistant to obesity. The researchers discovered that this variant behaves differently in the cell which may contribute to more efficient metabolism. The study, posted online in Molecular Metabolism […]
Vascular Conditions Offer No Clarity on Pollution-Dementia Link
Investigators appeared to rule out vascular dysfunction mediating the previously reported link between fine particulate matter (PM2.5) and dementia. Contrasting with prior studies, their nationally representative U.S. cohort study found no significant association between greater long-term exposure to PM2.5 and a higher dementia risk 10 years later (HR 1.04, 95% CI 0.98-1.11). Sensitivity analysis suggested […]
Researchers uncover why light-to-moderate drinking is tied to better heart health: The findings could help in identifying new interventions that reduce the brain’s stress activity without the negative health effects of alcohol
A new study led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, offers an explanation for why light-to-moderate alcohol consumption may be associated with lower risk of heart disease. For the first time, researchers found that alcohol, in light to moderate quantities, was associated with long-term reductions […]
Mediterranean diet linked to lower preeclampsia risk
In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, investigators from the Smidt Heart Institute at Cedars-Sinai found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy. The study, published today in the peer-reviewed journal JAMA Network Open, also evaluated the […]
Pragmatic Trials May Help Increase Minority Participation in MS Research
Pragmatic trials may offer one way to increase minority populations in multiple sclerosis (MS) studies, investigators for the DELIVER-MS trial suggested. Race and ethnicity did not appear to influence decisions to participate in either the randomized or observational cohorts of the pragmatic DELIVER-MS study, or in treatment choices, reported Sarah Planchon, PhD, of the Cleveland […]
Artificial intelligence tool may help predict heart attacks: Cedars-Sinai scientists developed an AI algorithm to measure coronary plaque buildup
Investigators from Cedars-Sinai have created an artificial intelligence-enabled tool that may make it easier to predict if a person will have a heart attack. The tool, described in The Lancet Digital Health, accurately predicted which patients would experience a heart attack in five years based on the amount and composition of plaque in arteries that […]
New discovery may help reduce side effects of multiple sclerosis drugs
Investigators from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments. The study, published Feb. 8 in Nature Communications, details the precise molecular structure of the multiple sclerosis drug siponimod as it interacts […]
Comprehensive clinical sequencing opens door to the promise of precision medicine
St. Jude Children’s Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine. Results from the St. Jude Genomes for Kids study appear online today in the journal Cancer Discovery. Whole genome and whole exome sequencing of germline […]