Intranasal Zavegepant Shows Promise in Acute Migraine
Zavegepant, an investigational nasal spray formulation of a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist, met its co-primary endpoints in a phase III randomized placebo-controlled trial of acute migraine. On both primary endpoints — 2-hour pain freedom (23.6% vs 14.9%, P<0.0001) and 2-hour freedom from most bothersome symptom (39.6% vs 31.1%, P=0.0012) — zavegepant was […]
Intratumoral Combo Shrinks Melanomas Refractory to Anti-PD-1
Intratumoral injection of an investigational agent, BO-112, combined with pembrolizumab (Keytruda) demonstrated promising efficacy in certain patients with advanced melanoma refractory to anti-PD-1-based therapy, according to results from a single-arm phase II trial. Ten of 40 evaluable patients responded to treatment — six partial and four complete responses — meeting the study’s primary endpoint of […]
Add-On Mavacamten Cuts Need for Septal Reduction in Obstructive HCM
WASHINGTON – Treatment with investigational mavacamten allowed patients with advanced obstructive hypertrophic cardiomyopathy (oHCM) to avoid septal reduction therapies (SRT), a researcher reported. In the VALOR-HCM study among 56 patients with documented oHCM who received add-on mavacamten to maximally-tolerated medical therapy, 17.9% met the composite endpoint (decision to move to SRT by week 16 or […]
Another China-Developed PD-1 Inhibitor Makes Its Case in NSCLC
Adding the investigational PD-1 checkpoint inhibitor toripalimab to chemotherapy in first-line significantly improved progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without EGFR/ALK mutations, according to results from a study conducted in China. Median PFS improved from 5.6 months with chemotherapy alone to 8.4 months with the toripalimab-based combination (HR 0.49, 95% […]
Investigational RSV Vaccine in Pregnancy Tied to Fewer Abx Scripts for Babies
Infants whose mothers received an investigational respiratory syncytial virus (RSV) vaccine in pregnancy had fewer antimicrobial prescriptions during their first 3 months of life, a post hoc secondary analysis of a randomized trial found. Across 11 countries, infants born to mothers assigned to the vaccine arm during pregnancy had a 12.9% (95% CI 1.3-23.1) lower […]
Drug mimics beneficial effects of fasting in mice: Blocking arginine metabolism leads to improved metabolic health, weight loss
An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, leading to improved weight control, according to a new study in mice from researchers at Washington University School of Medicine in St. Louis. The findings are published in the journal Cell Reports Medicine. In a group […]