Keytruda Plus T-VEC Falls Short in Unresectable Melanoma
Pembrolizumab (Keytruda) plus intratumoral talimogene laherparepvec (T-VEC, Imlygic) did not significantly improve survival in unresectable melanoma as compared with pembrolizumab alone, an international phase III trial showed. Although the combination improved median progression-free survival (PFS) by almost 6 months (14.3 vs 8.5 months), the difference did not achieve statistical significance (P=0.13). Median overall survival (OS) […]
Intratumoral Combo Shrinks Melanomas Refractory to Anti-PD-1
Intratumoral injection of an investigational agent, BO-112, combined with pembrolizumab (Keytruda) demonstrated promising efficacy in certain patients with advanced melanoma refractory to anti-PD-1-based therapy, according to results from a single-arm phase II trial. Ten of 40 evaluable patients responded to treatment — six partial and four complete responses — meeting the study’s primary endpoint of […]