Epinephrine Nasal Spray Starts Reversing Allergic Reactions in Minutes
WASHINGTON — Although FDA approval has eluded the intranasal epinephrine spray ARS-1 (also known as neffy), it continued to build its case with findings of resolved allergic symptoms in children and teenagers undergoing an oral food challenge, and with a separate study showing that it maintained its potency under extreme temperatures. In a small observational […]
No Survival Benefit to Higher Intranasal Naloxone Dose
There was no difference in survival between recipients of 4-mg or 8-mg intranasal naloxone (Narcan) administered by law enforcement, according to data from New York state. A review of 354 naloxone administration reports from New York State Police from March 2022 to August 2023 showed that 99% of people who received the 8-mg dose and […]
Fast-Acting Nasal Spray for Migraine Snags FDA Approval
The FDA approved intranasal zavegepant (Zavzpret) for acute migraine, making it the first calcitonin gene-related peptide (CGRP) receptor antagonist nasal spray with this indication, drugmaker Pfizer announced on Friday. Zavegepant is indicated for the treatment of migraine with or without aura, and is not indicated for preventing migraine. The pathophysiology of migraines is related to […]
Intranasal Saline May Suffice for Some Kids’ Sleep-Disordered Breathing
Intranasal mometasone furoate was no better than saline for resolving symptoms of sleep-disordered breathing (SDB) in children, but either treatment may reduce the need for specialty care or surgery, the randomized MIST trial suggested. After 6 weeks of daily treatment, the proportion experiencing the study’s primary endpoint — resolution of significant SDB symptoms — was […]
Advantages of intranasal vaccination against SARS-CoV-2: Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract
There are many reasons that an intranasal vaccine against the SARS-CoV-2 virus would be helpful in the fight against COVID-19 infections, University of Alabama at Birmingham immunologists Fran Lund, Ph.D., and Troy Randall, Ph.D., write in a viewpoint article in the journal Science. That route of vaccination gives two additional layers of protection over intramuscular […]