Blood plasma protein fibrinogen interacts directly with nerve cells to cause brain inflammation
Neuroinflammatory diseases, including Alzheimer’s disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen. These mesh-like fibrin deposits occur outside blood vessels in the brain, contributing to the death of certain central nervous system cells (neurons) that eventually leads to impaired […]
Novel small molecule potently attenuates neuroinflammation in brain and glial cells
Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation. In a preclinical study published in the journal […]
Preventing the long-term effects of traumatic brain injury: New study points to a potential new treatment that could prevent chronic complications
You’ve been in a car accident and sustained a head injury. You recovered, but years later you begin having difficulty sleeping. You also become very sensitive to noise and bright lights, and find it hard to carry out your daily activities, or perform well at your job. This is a common situation after a traumatic […]