Is Alzheimer’s Risk Lower With TNF Inhibitors?
Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer’s disease and related dementia, but only in people with cardiovascular disease, data from the DREAM (Drug Repurposing for Effective Alzheimer’s Medicines) study showed. Among more than 22,000 older adults, targeted disease-modifying antirheumatic drugs overall were not associated with a […]
Honing the Indications for Adjuvant CDK4/6 Inhibition in Breast Cancer
MIAMI BEACH — After a bumpy start, CDK4/6 inhibitors have started to gain traction in early hormone receptor (HR)-positive/HER2-negative breast cancer, according to recent data. Two negative phase III trials of palbociclib (Ibrance) questioned whether the transformative impact of CDK4/6 inhibition in advanced HR+/HER2- breast cancer would carry over into early disease. More recently, the […]