MRD Tied to Allo-Transplant Benefit in NPM1-Mutated Acute Myeloid Leukemia
SAN DIEGO — Measurable residual disease (MRD) after induction therapy can guide the use of allogeneic transplant in patients with NPM1-mutated acute myeloid leukemia (AML) in first remission, regardless of whether FLT3 internal tandem duplication (ITD) mutations are present as well, according to an analysis of two randomized trials. Of more than 700 patients in […]
Possible Role for Ipilimumab in Metastatic Bladder Cancer, Study Suggests
A tailored immunotherapy regimen using nivolumab (Opdivo) induction and “boosts” with nivolumab and high-dose ipilimumab (Yervoy) as second-line treatment for metastatic urothelial cancer was associated with higher response rates compared with historical controls, the phase II TITAN-TCC trial showed. Among 83 patients in the intention-to-treat (ITT) population, a confirmed investigator-assessed objective response occurred in 33% […]
Can Pre-Op Chemo Set Stage for Organ-Sparing Surgery in Early Rectal Cancer?
Three months of induction chemotherapy resulted in successful downstaging for certain patients with early-stage rectal cancer, enabling them to undergo organ-sparing therapy, according to a phase II trial. In 33 of 58 patients, induction with modified folinic acid, fluorouracil, oxaliplatin 6 (FOLFOX6) or capecitabine-oxaliplatin (CAPOX), followed by transanal excision surgery, resulted in downstaging to ypT0/1N0/X […]
New research provides clues to developing better intranasal vaccines for COVID-19 and flu
While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear. New research published this week in mBio,an open-access journal of the American Society for Microbiology, explores the role of nasal bacteria and […]