PROs for Cutaneous Chronic GVHD After Transplant Tied to Disease Severity, Mortality
Skin-involved chronic graft-versus-host disease (cGVHD) had a significant association with long-term impairment of patient-reported outcomes (PROs), which also had a prognostic association with mortality, a multicenter prospective study showed. Patients with sclerotic cGVHD had significantly worse scores on a validated quality-of-life (QOL) instrument compared with those who had epidermal-type cGVHD. Patients with combination GVHD subtypes […]
Impaired Neurodevelopment in Preemies Screened for Retinopathy: Nature or Nurture?
Having public health insurance was associated with an increased risk of neurodevelopmental impairment among infants screened for retinopathy of prematurity (ROP), a retrospective cohort study suggested. In a diverse cohort of 706 premature neonates, public heath insurance was associated with an increased risk of moderate to severe neurodevelopmental impairment in cognitive and language domains, and […]
Test Predicts Transition From Normal to Impaired Cognition
The Stages of Objective Memory Impairment (SOMI) system predicted transitions from normal cognition to incident symptomatic cognitive impairment, longitudinal data showed. Over a mean follow-up of about 6 years, cognitively normal older adults with memory tests scores reflecting moderate retrieval impairment (SOMI-2) were twice as likely to progress to incident cognitive impairment as those whose […]
Dementia Strikes One in Ten Americans Over 65
About one in 10 U.S. adults over 65 has dementia and even more have mild cognitive impairment, updated national estimates suggested. In a nationally representative cross-sectional study of about 3,500 older adults, 10% (95% CI 9-11) were classified as having dementia and 22% (95% CI 20-24) as having mild cognitive impairment, according to Jennifer Manly, […]
Persistent Olfactory Loss After COVID Predicts Cognitive Impairment
Persistent smell loss after SARS-CoV-2 infection predicted cognitive impairment in older adults, a longitudinal study in Argentina showed. One year after acute infection, anosmia was more strongly associated with cognitive impairment than severity of SARS-CoV-2 infection, reported Gabriela Gonzalez-Aleman, MSc, PhD, of Pontificia Universidad Católica Argentina in Buenos Aires, at the 2022 Alzheimer’s Association International […]
Regular Exercise Program May Stall Cognitive Decline
Sedentary older adults with amnestic mild cognitive impairment who engaged in regular exercise for a year maintained their cognition without decline, topline data from the EXERT trial showed. Older adults who engaged in either moderate intensity aerobic training or stretching, balance, and range-of-motion exercises for 12 months showed no change from baseline in ADAS-Cog-Exec scores, […]
A diet rich in plant-based products reduces the risk of cognitive impairment in the elderly: Metabolomics to study the impact of diet on health
A diet rich in plant products reduces the risk of cognitive impairment and dementia in the elderly. This is the result of a study by the Biomarkers and Nutritional Food Metabolomics Research Group of the Faculty of Pharmacy and Food Sciences of the University of Barcelona (UB) and the CIBER on Frailty and Healthy Aging […]
COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer’s Biomarkers
Cognitive impairment was correlated with persistent anosmia in older adults recovering from SARS-CoV-2 infection, initial findings from a large international consortium showed. Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2=13.82, P=0.003) but not with the severity of acute COVID-19, Gabriel de Erausquin, MD, PhD, MSc, of the University of Texas […]
For pediatric patients with Crohn’s disease, factors associated with statural growth differ by sex
Growth impairment, a common complication of Crohn’s disease in children, occurs more often in males than females, but the reasons are unclear. Now, a physician-scientist from Weill Cornell Medicine and NewYork-Presbyterian and colleagues at eight other centers have found that factors associated with statural growth differ by sex. Their recent publication, identified as the “Editor’s […]