Retinal OCT Shows Promise as Diagnostic Aid for Mild Cognitive Impairment
Aided by artificial intelligence, analysis of retinal images and related data identified condition-specific features that distinguished patients with mild cognitive impairment from those with normal cognition, a prospective study showed. The analytic model, used to evaluate optical coherence tomography (OCT) and OCT angiography (OCTA), detected changes in the retina and microcirculation that distinguished mild cognitive […]
Chemo-Free Approach Works in Subset of Patients With HER2+ Early Breast Cancer
CHICAGO — An “adaptive response” treatment strategy identified a subset of patients with HER2-positive early breast cancer who benefited from a chemotherapy-free treatment plan, according to the phase II PHERGain trial. The strategy is based on evaluating an early response to a dual HER2 blockade with trastuzumab (Herceptin) and pertuzumab (Perjeta) with 18F-FDG PET imaging […]
Genetic Risk Score Predicts Hypertensive Disorders of Pregnancy
With new genetic variants identified for preeclampsia and gestational hypertension, researchers created polygenic risk scores (PRS) that may better identify candidates for prophylactic low-dose aspirin among pregnant mothers. There were 18 independent genetic loci significantly associated with hypertensive disorders of pregnancy (HDPs) — 12 of them new (i.e., MTHFR-CLCN6, WNT3A, NPR3, PGR, and RGL3) — […]
Opinion | Marijuana Is Not the Solution for PTSD
A growing number of states have identified post-traumatic stress disorder (PTSD) as an approved condition for medical marijuana. According to Colorado’s Medical Marijuana Registry, there are 70,533 patients as of February 2023 with an active medical marijuana registration in the state, and 10,734 of them indicate PTSD as the reason they are using medical marijuana. […]
Novel PET Imaging Agent Accurately IDs Clear Cell Renal Cancers
An investigational PET imaging agent — zirconium-89 (89Zr)-deferoxamine (DFO)-girentuximab — identified clear cell renal cell carcinoma (ccRCC) with high sensitivity and specificity, according to results from the phase III ZIRCON trial. Use of the agent achieved sensitivity and specificity rates of 85.5% (95% CI 79.8-89.8) and 87% (95% CI 78.8-92.3), respectively, reported Peter Mulders, MD, […]
Pattern of gene activity for ADHD
Researchers at the National Institutes of Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), part of the NIH, found that individuals diagnosed with ADHD had differences in genes that code […]
Scientists redefine obesity with discovery of two major subtypes
A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication. The findings, published today in the journal Nature Metabolism, offer a more nuanced understanding of obesity than current definitions and may one day […]
What Is Langya? Here’s Everything We Know About The Virus So Far.
skynesher via Getty Images A new virus called Langrya has been identified by scientists after researchers recorded multiple cases in China. Langya henipavirus, also know as LayV, was first detected in the north-eastern provinces of Shandong and Henan in late 2018, though the virus was only properly identified by scientists last week. Advertisement So far, […]
Researchers identify a new mechanism responsible for controlling auditory sensitivity
A new study published in PNAS highlights a newly identified mechanism of how auditory sensitivity is regulated that could temporarily reduce sensitivity of the auditory system to protect itself from loud sounds that can cause irreversible damage. The study, led by CU Anschutz researchers Andrew Mecca and Giusy Caprara in the laboratory of Anthony Peng, […]
How sound reduces pain in mice: Newly identified brain circuits may point to more effective pain therapies
An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform development of safer methods to treat pain, were published in Science. The study was led by researchers at the National Institute of Dental and Craniofacial Research (NIDCR); the University of Science and Technology […]