Consolidation Intensification Fails in High-Risk Metastatic Ewing Sarcoma
Adding high-dose treosulfan and melphalan as further consolidation therapy for high-risk metastatic Ewing sarcoma failed to improve survival outcomes, a randomized phase III study showed. In an intention-to-treat population of 109 patients receiving standard induction and consolidation therapy, no significant difference was seen in event-free survival (EFS) between a group that also received high-dose treosulfan-melphalan […]
Largest Ivermectin Trial Fails to Show Benefit in COVID Outpatients
Early use of ivermectin in COVID-19 patients at high-risk for severe disease failed to lower the risk of hospitalization or prolonged emergency department (ED) observation, a large randomized trial showed. In an adaptive platform trial in Brazil, an intention-to-treat (ITT) analysis found that 14.7% of patients in the ivermectin group and 16.3% of patients in […]
FDA Authorizes One More Dose of Pfizer’s COVID Vaccine for Some
A third dose of Pfizer’s COVID-19 vaccine (Comirnaty) was authorized for use in older adults and high-risk populations, the FDA announced late on Wednesday. The agency amended Pfizer’s emergency use authorization (EUA) for the vaccine to include a third dose at least 6 months following the primary series in adults 65 and older, adults ages […]