A Win for Trabectedin in High-Grade Myxoid Liposarcoma?
Neoadjuvant trabectedin (Yondelis) for high-grade myxoid liposarcoma (HG-MLPS) demonstrated noninferiority to the long-time standard of anthracycline-ifosfamide (AI), according to new data from a previously completed trial. Standard therapy was associated with twice as many recurrences as compared with trabectedin, translating into a 40% reduction in the hazard for disease-free survival (DFS) in favor of trabectedin. […]
Cystic Renal Masses Often Harbor High-Grade Disease
Almost a fourth of renal cysts had pathologically high-grade disease, which did not have a correlation with growth rate or increase the risk with active surveillance (AS), according to a large retrospective review. Overall, 23% of 387 radiographically confirmed cystic lesions exhibited high-grade pathology. Nonetheless, the potentially more aggressive subset did not affect overall survival, […]
Ablating High-Grade Anal Lesions Thwarts Progression to Cancer
A protocol in which high-grade squamous intraepithelial lesions (HSIL) of the anal canal were immediately treated was more effective for preventing incidence of anal cancer in people with HIV, a randomized trial found. In the study involving nearly 4,500 individuals with anal HSIL detected by screening, nine of those assigned to aggressive therapy — mostly […]
Varying immune cell levels in canine brain tumors could provide therapeutic targets
A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas. The work, which is the most extensive examination of immune cell infiltration in canine glioma to date, adds to the body of evidence that these brain tumors might recruit cells that […]
Varying immune cell levels in canine brain tumors could provide therapeutic targets
A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas. The work, which is the most extensive examination of immune cell infiltration in canine glioma to date, adds to the body of evidence that these brain tumors might recruit cells that […]