Standard Lymphoma Therapies Tied to Higher Risk for New Malignancies
Use of high-dose chemotherapy and autologous hematopoietic stem-cell transplantation (HSCT) for patients with aggressive lymphoma was associated with an increased risk of certain second primary malignancies (SPMs), according to a retrospective Danish population-based cohort study. The overall SPM rate was higher among lymphoma patients compared with matched controls from the general population (HR 2.35, 95% […]
Shorter TB Regimen Misses the Mark
Shorter high-dose rifampicin regimens proved safe for treating pulmonary tuberculosis (TB), but failed to demonstrate noninferiority compared with the standard 6-month regimen, a phase III trial found. For the primary efficacy outcome, an absolute 6.3% more adults receiving a 4-month regimen that included the highest dose of rifampicin had an unfavorable outcome at 12 to […]
Hemodiafiltration Reduced Dialysis Mortality in Kidney Failure
High-dose hemodiafiltration improved survival compared with standard hemodialysis for patients with kidney failure resulting in the need for kidney-replacement therapy, according to the randomized CONVINCE trial. High-dose hemodiafiltration cut all-cause mortality to 17.3% compared with 21.9% on conventional high-flux hemodialysis over a median 30 months of follow-up (HR 0.77, 95% CI 0.65-0.93), reported researchers led […]
Green tea extract may harm liver in people with certain genetic variations
Long-term use of high-dose green tea extract may provide some protection against cancer, cardiovascular disease, obesity and type 2 diabetes, but it also may create liver damage in a small minority of the population. Who is at risk? Research from Rutgers, published in The Journal of Dietary Supplements, provides the first solid clue: two genetic […]
High-Dose Flu Vaccine Promising for Mortality Benefits in Older Adults
BARCELONA – A Danish feasibility study that tested a high-dose quadrivalent influenza vaccine versus a standard dose hinted at morbidity and mortality benefits, researchers reported. In the DANFLU-1 study, there was a 48.9% reduction in the risk of all-cause mortality and a 64% reduction in the incidence of hospitalization for influenza or pneumonia for high-dose […]
Vitamin B6 supplements could reduce anxiety and depression
Taking high-dose Vitamin B6 tablets has been shown to reduce feelings of anxiety and depression by new research. Scientists at the University of Reading measured the impact of high doses of Vitamin B6 on young adults and found that they reported feeling less anxious and depressed after taking the supplements every day for a month. […]
Consolidation Intensification Fails in High-Risk Metastatic Ewing Sarcoma
Adding high-dose treosulfan and melphalan as further consolidation therapy for high-risk metastatic Ewing sarcoma failed to improve survival outcomes, a randomized phase III study showed. In an intention-to-treat population of 109 patients receiving standard induction and consolidation therapy, no significant difference was seen in event-free survival (EFS) between a group that also received high-dose treosulfan-melphalan […]
Simpler Antifungal Course Works for Cryptococcal Meningitis in Africa
A single high-dose course of liposomal amphotericin B as part of a three-drug antifungal treatment regimen was non-inferior to the current WHO-backed antifungal drug regimen for cryptococcal meningitis in people living with HIV, according to a phase III trial. In an intention-to-treat (ITT) analysis of 814 patients, 101 deaths were reported in the intervention group […]
High-Dose HBV Revaccination Better Protects HIV Patients
In HIV patients who failed to achieve protection from the hepatitis B virus (HBV) vaccine, a high-dose revaccination schedule led to better serological responses versus standard dosing, a randomized single-center trial in Chile showed. In an intention-to-treat analysis involving over 100 patients, 72% of those revaccinated with three doses of a high-dose recombinant HBV vaccine […]