Financial Toxicity in Cancer: A Possible Solution
Topic: In recent years, more and more people have referred to the high cost of cancer care as “financial toxicity.” How did “expensive” or “costly” evolve into “toxic?” What factors contributed to the evolution? What can be done about it? Join MedPage Today and Derek Raghavan, MD, PhD, president of the Levine Cancer Institute in […]
Skin Test Detects Parkinson’s and Other Synucleinopathies
Skin biopsies detected phosphorylated alpha-synuclein in a high proportion of people with Parkinson’s disease and other synucleinopathies. Finding a reliable diagnostic biomarker for synucleinopathies is an urgent unmet need. Further research is needed in other clinical populations to validate these findings. Skin biopsies detected cutaneous phosphorylated alpha-synuclein (p-syn) in a high proportion of people who […]
Small amounts of licorice raise blood pressure, study finds
It is known that large amounts of liquorice cause high blood pressure. A study by researchers at Linköping University, Sweden, now shows that even small amounts of liquorice raise blood pressure. The individuals who react most strongly also show signs of strain on the heart. Liquorice is produced from the root of plants of the […]
Feeling Congested? These Foods And Drinks Could Be To Blame
Carlo A via Getty Images Steer clear of the bacon! It can be high in histamines. You know that feeling you get when you’re stuffy, that your sinuses ache and you feel like you can’t breathe? Whether you’re fighting a cold, dealing with allergies or breathing in air pollution, there are many reasons your nose […]
Novel Regimens Yield High Response Rates for Older, Hodgkin Lymphoma Patients
Older patients with classical Hodgkin lymphoma unsuitable for conventional chemotherapy had high rates of durable responses with two brentuximab vedotin (BV; Adcetris) regimens, one that omitted chemotherapy, a small prospective study showed. Brentuximab plus the alkylating agent dacarbazine (DTIC) produced an objective response rate (ORR) of 95% in 22 patients, whereas brentuximab plus nivolumab (Opdivo) […]
Long-Acting Injectable Comparable to Oral ART for HIV in Sub-Saharan Africa
DENVER — Long-acting cabotegravir/rilpivirine (Cabenuva) injectable therapy resulted in similarly high levels of viral suppression to oral antiretroviral therapy (ART) in African patients with HIV, a phase IIIb randomized, open-label trial showed. At 48 weeks, 96.9% of participants receiving cabotegravir/rilpivirine had a viral load of less than 50 copies/mL compared with 97.3% of those receiving […]
Novel Hepatitis E Vaccine Protects for at Least a Decade
A three-dose vaccine regimen prevented hepatitis E virus (HEV) infections with high efficacy in adults over the course of 10 years, a phase III trial from China found. The HEV239 vaccine, sold under the name Hecolin outside the U.S., had an efficacy rate of 83.1% (95% CI 69.4-91.4) in the study’s modified intention-to-treat analysis and […]
High Response Rates in Psoriasis With Oral IL-23 Inhibitor
An oral interleukin (IL)-23 inhibitor for psoriasis produced 16-week response rates as high as 79% in moderate-to-severe plaque psoriasis, a prospective phase II trial showed. The drug (JNJ-77242113) achieved response rates of 37% to 79% across five dose levels. In contrast, patients treated with placebo had a 9% response rate at 16 weeks. The most […]
FDA Advisory Panel Generally Pleased With Pulse Oximetry Clinical Trial Proposal
An FDA advisory committee gave generally high marks to the agency’s latest effort to improve the accuracy of pulse oximeters when used in darker-skinned patients, but raised questions about some of the FDA’s proposed premarket clinical trial guidance for pulse oximeter manufacturers. “I really applaud the efforts of the FDA to reduce disparate bias in […]
Healthy diet early in life seems to protect against inflammatory bowel disease
Having a high dietary intake of fish and vegetables at 1 year of age, and a low intake of sugar beverages, seems to protect against inflammatory bowel disease. These are the findings of a study with more than 80,000 children conducted at the University of Gothenburg. The global rise in inflammatory bowel disease (IBD), which […]