Alternative Endpoints in Phase III Trials Don’t Always Mean Boosts to OS, QOL
CHICAGO — Late-phase trials that showed superiority for an experimental intervention on a surrogate endpoint did not necessarily lead to improvements in overall survival (OS) or quality of life (QOL), according to a meta-epidemiologic analysis. Alexander Dean Sherry, MD of the MD Anderson Cancer Center in Houston, and colleagues evaluated 791 randomized controlled trials (RCTs) […]
Rhythmic eating pattern preserves fruit fly muscle function under obese conditions
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels. Interestingly, studies in various animal models have […]
Anti-butterfly effect enables new benchmarking of quantum-computer performance: Running a quantum system backward, then forward in time distinguishes information leaks from the desired information scrambling
Research drawing on the quantum “anti-butterfly effect” solves a longstanding experimental problem in physics and establishes a method for benchmarking the performance of quantum computers. “Using the simple, robust protocol we developed, we can determine the degree to which quantum computers can effectively process information, and it applies to information loss in other complex quantum […]
Lab earthquakes show how grains at fault boundaries lead to major quakes: Faults once thought to be ‘creeping’ yet stable may be at risk for big ruptures
By simulating earthquakes in a lab, Caltech engineers have provided strong experimental support for a form of earthquake propagation now thought responsible for the magnitude-9.0 earthquake that devastated the coast of Japan in 2011. Along some fault lines, which are the boundaries of tectonic plates, a fine-grained gravel is formed as the plates grind against […]
Experimental drug boosts immunotherapy effectiveness in pancreatic cancer in mice
An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer. The findings, from researchers at Georgetown Lombardi Comprehensive Cancer Center and BioXcel […]