At Long Last, Hard Data to Support Artificial Urinary Sphincter in Male Incontinence
LAS VEGAS — After decades of use, the artificial urinary sphincter (AUS) finally has high-level evidence of its safety and efficacy for stress urinary incontinence (SUI) in men. What’s more, patients like it. More than 90% of patients had at least a 50% reduction in sanitary pad weight over 12 months; daily pad use declined […]
Havana Syndrome Mystery Continues to Deepen
Despite persistent symptoms, no significant evidence of brain injury and no abnormalities in most clinical measures were found in U.S. government personnel who experienced anomalous health incidents (AHIs) known as Havana syndrome, NIH researchers said. After adjusting for multiple comparisons, no differences in MRI measures of brain structure or function emerged between individuals with AHIs […]
Why Aren’t More Doctors Prescribing Paxlovid to High-Risk Patients?
Recent evidence is piling up that many people at high risk for severe COVID-19 don’t receive nirmatrelvir/ritonavir (Paxlovid) — or any outpatient antiviral treatment — when diagnosed with a SARS-CoV-2 infection. MedPage Today looked at new studies and talked to experts to find out why. In a new observational study, people on Medicare who were […]
Drug Candidate for Chronic Cough Rejected by FDA Panel
FDA advisors told the agency that the current evidence does not support approval of gefapixant for chronic cough, a condition where no approved therapy exists. On Friday, members of the Pulmonary-Allergy Drugs Advisory Committee voted 12-1 that the small reductions in cough frequency demonstrated in phase III trials of the P2X3 receptor antagonist do not […]
The microbiome of fruit and vegetables positively influences diversity in the gut
In a meta-study, a research team from the Institute of Environmental Biotechnology at TU Graz has provided evidence that the consumption of fruit and vegetables contributes positively to bacterial diversity in the human gut. Bacterial diversity in the gut plays an important role in human health. The crucial question, however, is where are the sources […]
Link Between Psoriasis, Heart Disease Tracks to Coronary Microvascular Dysfunction
Almost a third of patients with severe psoriasis had echocardiographic evidence of asymptomatic coronary microvascular dysfunction (CMD), a prospective study showed. Doppler echocardiography showed that 31.5% of 448 patients with psoriasis had CMD. Every 1-point increase in the Psoriasis Area and Severity Index (PASI) score and 1-year increase in psoriasis duration correlated with a 5% […]
Study Links Being Breastfed to Cancer Risk in Adulthood
Additional evidence for a possible link between breastfeeding and colorectal cancer (CRC) was found in a large cohort study. In two prospective cohorts of 158,696 women followed for more than 20 years, being breastfed in infancy was associated with a 23% increased risk of CRC in adulthood (HR 1.23, 95% CI 1.10-1.38, P<0.001), Chen Yuan, […]
Link found between childhood television watching and adulthood metabolic syndrome
A University of Otago study has added weight to the evidence that watching too much television as a child can lead to poor health in adulthood. The research, led by Professor Bob Hancox, of the Department of Preventive and Social Medicine, and published this week in the journal Pediatrics, found that children who watched more […]
Sarepta’s Duchenne Gene Therapy Does Not Have ‘Unambiguous Evidence,’ FDA Staff Says
Clinical studies to date “do not provide unambiguous evidence” for SRP-9001 (delandistrogene moxeparvovec), an investigational gene therapy for ambulatory Duchenne muscular dystrophy patients, FDA reviewers said in briefing documents released ahead of an advisory committee meeting. The agency also raised safety concerns about the possibility of administering an ineffective gene therapy. Duchenne muscular dystrophy is […]
Sotatercept, Fixed-Dose Combo Therapy on the Right Path for PAH
NEW ORLEANS — The limited clinical evidence thus far supports investigational compounds for addition to or simplification of existing frontline therapies for pulmonary arterial hypertension (PAH), according to two trials presented here at the American College of Cardiology (ACC) annual meeting. The activin signaling inhibitor biologic sotatercept showed promise as an add-on to usual treatment […]