What Is Tianeptine and Why Is It in Demand?
An uptick in adverse events connected to unregulated tianeptine products — often referred to as “gas station heroin” — along with the voluntary recall of a popular product have brought renewed attention to the atypical tricyclic antidepressant. Earlier this week, the company that makes a product called Neptune’s Fix issued a voluntary recall of several […]
Rare Syndrome After COVID Vaccines Described
People who experienced rare long-term adverse events after COVID-19 vaccination often had neurologic symptoms, survey data showed. Among 241 people who self-reported a post-vaccination syndrome (PVS), the five most common symptoms were exercise intolerance (71%), excessive fatigue (69%), numbness (63%), brain fog (63%), and neuropathy (63%), reported Harlan Krumholz, MD, of Yale School of Medicine […]
Recreational Drug Use More Common in Intensive Cardiac Care Than Many Admit
Many recreational drug users suffering acute cardiovascular events ended up in cardiac intensive care units (ICUs) without disclosing their drug use, according to the ADDICT-ICCU study conducted across France. The incidence of a positive drug screen was 11% among 1,499 consecutive patients admitted for acute cardiovascular events, with systematic urine testing revealing use of cannabis […]
Vitamin D for Cardiovascular Prevention Runs Into Another Wall
Monthly super-sized vitamin D supplements failed to significantly reduce major cardiovascular events in older adults, the Australian D-Health Trial found. Over up to 5 years of treatment, incident myocardial infarction (MI), stroke, and coronary revascularization turned up in 6% of the vitamin D group and 6.6% of the placebo group (HR 0.91, 95% CI 0.81-1.01), […]
Bempedoic Acid Gets ‘Huge’ Win for Primary Prevention in the Statin-Intolerant
SAN DIEGO — Bempedoic acid (Nexletol) prevented cardiovascular events in high-risk, statin-intolerant patients who had not yet had an event, a subgroup analysis from the CLEAR Outcomes trial confirmed. In these patients, bempedoic acid was associated with a large decrease in risk of major adverse cardiovascular events (MACE) compared with placebo over a median 39.9 […]
No Increase in Major Cardiac Events With Testosterone-Replacement Therapy
CHICAGO — Testosterone-replacement therapy was noninferior to placebo in the occurrence of major adverse cardiac events among men with hypogonadism and established or high risk for cardiovascular disease, the randomized TRAVERSE trial showed. At a mean follow-up of 33 months, the primary cardiovascular endpoint — first occurrence of any component of a composite of death […]
Neurologic Events After COVID-19 Vaccines Assessed
All patients hospitalized with new or relapsing neurologic events after SARS-CoV-2 vaccination at a New York tertiary hospital had one or more risk factors for their neurologic condition, a prospective study showed. The most prominent neurologic index events in these vaccinated patients were ischemic stroke (37.7%), encephalopathy (32.6%), seizure (15.9%), and intracranial hemorrhage (ICH; 9.4%), […]
Scoliosis Cramps Heart Function in Adulthood
Scoliosis was associated with altered cardiac function and an increase in cardiac events among adults in the U.K. Biobank, researchers found. Compared with peers without scoliosis, those with such sideways spinal curvature exhibited a greater lifetime risk of major adverse cardiovascular events (MACE; HR 1.45, P<0.001), driven by heart failure (HR 1.58, P<0.001) and atrial […]
Higher vitamin K intake linked to lower bone fracture risk late in life
Breaking bones can be life-changing events — especially as we age, when hip fractures can become particularly damaging and result in disability, compromised independence and a higher mortality risk. But research from Edith Cowan University’s Nutrition and Health Innovation Research Institute has revealed there may be something you can do to help reduce your risk […]
Surgery Bests Endovascular Therapy for Most Limb-Threatening Ischemia Patients
CHICAGO — Surgical revascularization led to fewer major adverse limb events and deaths compared with endovascular therapy in patients with chronic limb-threatening ischemia, according to the prospective randomized BEST-CLI trial. After a median follow-up of 2.7 years, the primary composite outcome of major adverse limb events and death from any cause occurred in 42.6% of […]