Isotretinoin REMS Still Needed, But Its Burden Could Be Reduced, FDA Staff Says
A risk evaluation and mitigation strategy (REMS) for the use of isotretinoin to treat severe acne is still very much needed, but there are ways to lighten its burden on patients and providers, according to FDA staff. For example, because of the drug’s risk of causing birth defects if taken while patients are pregnant, prescribing […]
The Immune Signature of Long COVID
In this exclusive video, Harlan Krumholz, MD, director of the Center for Outcomes Research and Evaluation at Yale University and Yale New Haven Hospital in Connecticut, discusses a recent preprint on distinguishing long COVID through immune profiling. Krumholz, a cardiologist, is also the Harold H. Hines, Jr. Professor of Medicine and a professor in the […]
Liver Fibrosis Linked to Lower Response to COVID Vaccine
An evaluation of antibody titers developed in response to the Pfizer-BioNTech mRNA COVID-19 vaccine appeared to show a correlation between low response and advanced liver fibrosis, researchers from Israel reported. In a cohort of 140 patients with non-alcoholic fatty liver disease, the more advanced the fibrosis was, the less of a response patients had to […]