Hypofractionated RT for Breast Cancer Post-Mastectomy as Effective as Standard RT
SAN DIEGO — Hypofractionated radiation appeared to be as safe and effective as conventionally fractionated radiation therapy for patients with breast cancer who underwent implant-based breast reconstruction following mastectomy, according to results from the FABREC randomized trial. For the study’s primary outcome of change in physical well-being score, patients in both groups reported similar scores […]
SABR Offers New Hope for Older Patients With Inoperable Kidney Cancer
SAN DIEGO — Stereotactic ablative body radiotherapy (SABR) was an effective, noninvasive strategy for treating primary renal cell carcinoma (RCC) in patients who were not suitable for surgery, according to the FASTRACK II trial. In the prospective, phase II study of 70 patients, none had local progression of kidney cancer during the trial lifetime (median […]
Early treatment of child obesity is effective
The early treatment of obesity in children is effective in both the short and long term, researchers from Karolinska Institutet report in a study published in The International Journal of Obesity. The researchers followed over 170 young children in Sweden who had received treatment for diagnosed obesity. The children were recruited to the randomised controlled […]
Pulsed Field Ablation Measures Up in Head-to-Head Trial
AMSTERDAM — Pulsed field ablation appeared as safe and effective as thermal ablation in treating paroxysmal atrial fibrillation (Afib) in the first randomized head-to-head trial for the novel technology. Efficacy failure of the procedure — initial procedural failure, documented atrial tachyarrhythmia after a 3-month blanking period, antiarrhythmic drug use, cardioversion, or repeat ablation — at […]
Pediatric Asthma Risk Score Robust Across Diverse Backgrounds
The Pediatric Asthma Risk Score (PARS) remained an effective tool for estimating asthma risk when used for patients of varying backgrounds, a study of 10 cohorts found. The area under the receiver operating curve (AUC) for the PARS assessment was 0.76 (95% CI 0.74-0.78), with AUC scores ranging from 0.61-0.83 across the cohorts, reported Gurjit […]
Adcetris Plus Chemo Effective in HIV-Related Hodgkin Lymphoma
Brentuximab vedotin (Adcetris) in combination with doxorubicin, vinblastine, and dacarbazine (AVD) was effective for patients with HIV-related stages II-IV classical Hodgkin lymphoma (cHL), according to results from the phase I/II AMC-085 study. All 37 patients who completed therapy in the 41-patient trial achieved a complete response; at 2 years, the progression-free survival (PFS) rate reached […]
Xeljanz Edges Humira Just a Bit for Real-World RA Patients, Study Suggests
Tofacitinib (Xeljanz) appeared ever-so-slightly more effective than adalimumab (Humira) for rheumatoid arthritis (RA) in a study that used real-world patient data to simulate a randomized head-to-head trial. Leaders of Australia’s OPAL network of rheumatologists reported that, among 699 RA patients starting their first biologic or targeted therapy for the disease, the mean 28-joint Disease Activity […]
Mirikizumab Benefit in UC Extends Into Maintenance Phase
The investigational monoclonal antibody mirikizumab was more effective in inducing and maintaining clinical remission in patients with moderate to severe ulcerative colitis (UC) compared with placebo, according to two phase III randomized trials. Among over 1,200 patients in the LUCENT-1 induction trial, 24.2% of those who received mirikizumab experienced clinical remission at week 12 compared […]
Blinatumomab Plus Chemo Effective in Aggressive Infant ALL
Adding a postinduction course of blinatumomab (Blincyto) to chemotherapy appeared safe and highly effective for treating an aggressive form of acute lymphoblastic leukemia (ALL) in infants, according to results from a phase II study. Of the 30 infants with newly diagnosed KMT2A-rearranged ALL, 16 achieved minimal residual disease (MRD)-negative status following the 28-day infusion with […]
Taxane, Anthracycline Combo Most Effective in Reducing Breast Cancer Recurrence
Combining anthracycline and taxane for early-stage operable breast cancer was more effective than either anthracycline or taxane chemotherapy alone in reducing breast cancer recurrence and death, according to a meta-analysis. Moreover, regimens with higher cumulative doses of anthracycline plus taxane were associated with the greatest benefit, according to a report from Jeremy Braybrooke, BM, PhD, […]