Global Incidence of Early-Onset Cancer Has Surged Since 1990
The global incidence of early-onset cancer has increased by 79% over the last three decades, researchers reported. In 2019, new cancer diagnoses in people under 50 totaled 3.26 million compared with 1.82 million in 1990, according to Xue Li, PhD, of Zhejiang University School of Medicine in China, and colleagues. Meanwhile, 1.06 million people under […]
High-Dose Leptin Reversed Severe Genetic Obesity in Two Patients
Personalized recombinant leptin treatment helped reverse severe, early-onset obesity in two children carrying rare antagonistic leptin genetic variants, a study showed. In the double case report, two unrelated children — a 14-year-old boy and a 2-year-old girl — presented with what appeared to be leptin dysfunction, marked by intense hyperphagia, lack of satiety, and severe […]
Blood Type Tied to Early-Onset Stroke Risk
Two variants in ABO, a known stroke locus, were linked with early-onset ischemic stroke risk, a meta-analysis of genome-wide association studies (GWAS) showed. The variants tagged blood type subgroups O1 and A1, and effect sizes were significantly larger in early-onset (under age 60) than late-onset stroke, reported Braxton Mitchell, PhD, MPH, of University of Maryland […]
Presepsin a ‘Robust’ Biomarker of Early-Onset Sepsis
Presepsin holds promise as a biomarker for early-onset sepsis (EOS), a systematic review and meta-analysis confirmed. Across a dozen clinical trials, presepsin had a pooled sensitivity of 0.93 for the primary analysis of culture-proven sepsis (95% CI 0.86-0.96), a pooled specificity of 0.91 (95% CI 0.85-0.95), and a pooled diagnostic odds ratio (DOR) of 131.7 […]