FDA Panel Gives Thumbs Up to Earlier Use of CAR T-Cell Therapy in Multiple Myeloma
Two CAR T-cell therapies for multiple myeloma won favorable recommendations for earlier use in the disease during a day-long meeting of the FDA Oncologic Drugs Advisory Committee (ODAC). By an 11-0 vote, ODAC recommended that FDA approve ciltacabtagene autoleucel (cilta-cel, Carvykti) for use as second-line therapy in certain patients with myeloma. Later in the day, […]
Clinical Challenges: Using Pola-R-CHP for Diffuse Large B-Cell Lymphoma
Earlier this year, the FDA approved a new frontline option for patients with diffuse large B-cell lymphoma (DLBCL): the antibody-drug conjugate polatuzumab vedotin (Polivy) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (pola-R-CHP). Combination chemotherapy involving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) — and before that, CHOP alone — has been the established option […]
Experts Quell Worries About Locally Acquired Malaria in the U.S.
Earlier this week, the CDC issued an alert on the first locally acquired malaria cases in the U.S. in 20 years. MedPage Today spoke with experts and physicians to determine how rare the cases are, whether there may be more, and what may have contributed to them. Within the last 2 months, four locally acquired […]
Introducing Allergenic Foods Early Tied to a Reduction in Later Allergies
Earlier introduction of common allergenic foods in the first year of life was linked to a lower risk of immunoglobulin E (IgE)-mediated food allergy from 1 to 5 years of age, according to a systematic review and meta-analysis of 23 randomized trials. Moderate-certainty evidence from four trials (n=3,295) showed that the introduction of multiple allergenic […]
For Septic Shock, Another Toss-up Between Emphasizing Vasopressors Vs Fluids
SAN FRANCISCO — For sepsis-induced hypotension, a restrictive fluid strategy with earlier vasopressor use didn’t impact mortality compared with liberal fluids, the CLOVERS trial showed. The restrictive strategy had its intended effect, reducing median IV fluids administered over 24 hours by 2,134 mL in favor of more vasopressor use compared with the liberal fluids strategy […]
Early tastings shorten breastfeeding
The earlier infants begin to taste small samples of solid food, the earlier they eat more food and stop breastfeeding. This is shown in a new study from Uppsala University and Sophiahemmet University, in which the mothers of 1,251 infants from all over Sweden participated. Almost half of the infants received tastings at the age […]
For People With HIV, Early Anal Cancer Screening Tied to Better Outcomes
Screening HIV-positive individuals for early signs of anal cancer may lead to an earlier diagnosis and better survival, according to an observational Dutch cohort study. Among men who have sex with men (MSM) living with HIV, anal cancer-related mortality was 3.7% in those who had been screened in the Netherlands compared with 24.0% in those […]
Can Biomarkers Give Early Heads-Up on Immune Checkpoint Inhibitor Myocarditis?
In the quest to catch myocarditis earlier during immune checkpoint inhibitor (ICI) therapy for cancer, researchers have found a potential role for routinely measured biomarkers. Of 2,606 consecutive ICI recipients at Michigan Medicine, the 1% who developed myocarditis often or always had elevated high-sensitivity troponin T (hsTnT; 100%), alanine aminotransferase (ALT; 88.9%), aspartate aminotransferase (AST; […]
Teen Dies After Doctors Misdiagnose Tampon Infection
A 13-year-old girl from England died from Toxic Shock Syndrome earlier this year when doctors misdiagnosed her condition.
Tenofovir, Vaccine Combo Eliminates Mom-to-Child HBV Transmission
Earlier maternal tenofovir disoproxil fumarate (TDF) combined with infant vaccination completely eliminated vertical transmission of chronic hepatitis B virus (HBV) from highly viremic mothers, even without the use of hepatitis B immunoglobulin (HBIg), a randomized trial conducted in China found. At 28 weeks postpartum, mother-to-child transmission was an identical 0% with early maternal TDF therapy […]