Mutation Linked to Increased Risk of Prostate Cancer Mortality
The risk of dying of prostate cancer doubled in the presence of a genetic mutation affecting testosterone production, a large prospective cohort study showed. The 5-year risk of prostate cancer-specific mortality (PCSM) increased from 1.7% to as much as 4%, depending on the genotype of the HSD3B1(1245C) allele. In a subgroup of patients with metastatic […]
More Men Are Expressing Interest in Vasectomy After SCOTUS Abortion Decision
CHICAGO — Vasectomy consults more than doubled in the first 3 months after the Supreme Court decision overturning national abortion rights, according to data from one large health system. From June 24 — the day the Dobbs v. Jackson Women’s Health Organization decision was announced — until Sept. 24, 2022, a total of 342 vasectomy […]
Lousy Sleep Compounds Genetic Risk for Asthma in Adults
Poor sleep patterns and high genetic susceptibility together doubled the risk of asthma development in adults, a prospective study using U.K. Biobank data found. Individuals in the study who had the highest polygenic risk score (PRS) or were poor sleepers had a 47-55% higher risk for asthma over a median 8 years of follow-up compared […]
High Rates of pCR With Novel Neoadjuvant Combination for Breast Cancer
SAN ANTONIO — A novel neoadjuvant regimen for HER2-negative breast cancer doubled the pathologic complete response (pCR) rate as compared with standard chemotherapy, a small phase II study showed. Across various breast cancer receptor signatures, pCR rates ranged from 36% to 53% with the combination of paclitaxel, the PD-1 inhibitor cemiplimab (Libtayo), and the investigational […]
Two Sides of Endosalpingiosis: Benign Growth or Harbinger of Cancer?
The ectopic endothelial abnormality endosalpingiosis doubled the likelihood of concurrent gynecologic malignancy as compared with endometriosis and conferred worse overall survival (OS), a retrospective case-control study showed. Among 515 patients with endosalpingiosis, 40.1% had concurrent cancer as compared with 18% of patients who had endometriosis. The significant association between endosalpingiosis and malignancy persisted after exclusion […]
I Saw Blood In The Toilet. I Never Expected A Common Drug Could Be The Cause.
When I saw the blood in the toilet bowl, I decided it was time to go to the emergency room. I had been doubled over in pain for the better part of three hours. It started out as par for the course: I had grown accustomed to semi-regular stomach problems that left me stuck in […]