Tenofovir, Vaccine Combo Eliminates Mom-to-Child HBV Transmission
Earlier maternal tenofovir disoproxil fumarate (TDF) combined with infant vaccination completely eliminated vertical transmission of chronic hepatitis B virus (HBV) from highly viremic mothers, even without the use of hepatitis B immunoglobulin (HBIg), a randomized trial conducted in China found. At 28 weeks postpartum, mother-to-child transmission was an identical 0% with early maternal TDF therapy […]
Relapse Patterns in Chronic Hep B After Halting Treatment
Chronic hepatitis B patients who discontinued tenofovir disoproxil fumarate (TDF, Viread) after achieving viral suppression had higher rates of clinical relapse compared to those who stopped entecavir, a global retrospective study found. At 6 and 24 months, clinical relapse rates after stopping TDF grew from 31% to 58%, which was significantly higher than after entecavir […]