SABR Offers New Hope for Older Patients With Inoperable Kidney Cancer
SAN DIEGO — Stereotactic ablative body radiotherapy (SABR) was an effective, noninvasive strategy for treating primary renal cell carcinoma (RCC) in patients who were not suitable for surgery, according to the FASTRACK II trial. In the prospective, phase II study of 70 patients, none had local progression of kidney cancer during the trial lifetime (median […]
Protocol Optimizing Meds for T2D and CVD Pushed Beyond Cardiology Alone
SAN DIEGO — Cardiovascular medications were better optimized for patients with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD) following a multifaceted intervention involving clinician and patient education, the cluster-randomized COORDINATE-Diabetes trial found. At cardiology clinics following the intervention protocol, prescriptions increased several-fold compared with usual care (37.9% vs 14.5%; adjusted OR 4.28, 95% […]
Novel Triple Agonist Nabs Biggest Weight Loss Yet in Obesity Trial
SAN DIEGO — An investigational triple-hormone receptor agonist yielded major weight loss in people with obesity, a phase II trial showed. By 24 weeks, patients on any of the four doses of once-weekly injectable retatrutide lost a significantly greater amount of weight than those on placebo — achieving the trial’s primary endpoint — reported Ania […]
Bempedoic Acid Gets ‘Huge’ Win for Primary Prevention in the Statin-Intolerant
SAN DIEGO — Bempedoic acid (Nexletol) prevented cardiovascular events in high-risk, statin-intolerant patients who had not yet had an event, a subgroup analysis from the CLEAR Outcomes trial confirmed. In these patients, bempedoic acid was associated with a large decrease in risk of major adverse cardiovascular events (MACE) compared with placebo over a median 39.9 […]
Once-Weekly Insulin Icodec Bests Daily Insulin Options for Type 2 Diabetes
SAN DIEGO — Investigational once-weekly insulin icodec outperformed once-daily insulin glargine U100 when it came to glycemic control in type 2 diabetes, the phase IIIa ONWARDS 1 trial found. Over the course of 52 weeks, people with type 2 diabetes saw a greater average reduction in HbA1c with icodec compared with glargine U100 (estimated between-group […]
Near 15% Weight Loss With Novel Oral GLP-1 RA in Phase II Obesity Trial
SAN DIEGO — Orforglipron, an investigational nonpeptide GLP-1 receptor agonist, helped people with obesity lose a significant amount of weight in a phase II trial. Tested at four once-daily doses — 12, 24, 36, or 45 mg — patients on orforglipron lost between 8.6% to 12.6% of body weight compared with a 2% change seen […]
Lifestyle Factors and Glaucoma: Lots of Common Sense, Not So Much Evidence
SAN DIEGO — Limited data support a role for lifestyle factors in the prevention or management of glaucoma, according to a review presented here. Intuitively, diet, mental health, and good posture should contribute to good eye health, but the evidence does not support the intuition. Despite the dearth of positive studies, a better-safe-than-sorry approach remains […]
Artificial Intelligence Creates Inroads to Ophthalmology Clinical Practice
SAN DIEGO — As some experts sound the alarm about the potential dangers of artificial intelligence (AI), ophthalmologists have begun embracing AI as a means to improve the quality and efficiency of patient care. During a first-of-its-kind session at the American Society of Cataract and Refractive Surgery meeting, speakers discussed ongoing efforts to develop and […]
Kevin Smith Says He Checked Into A Facility After ‘Scary’ Mental Health Emergency
Kevin Smith at San Diego Comic-Con in 2022. Michael Kovac via Getty Images Kevin Smith is opening up about how he learned he was minimizing traumatic experiences from his childhood, hoping others also realize that “trauma is trauma.” The “Clerks” filmmaker told People in an exclusive profile published Wednesday that in January, he woke up […]
Can Oncologists Reduce the Suicide Risk in Their Prostate Cancer Patients?
SAN DIEGO — Whether it’s due to the side effects of local and systemic therapies, or the diagnosis itself, men with prostate cancer are at increased risk of mental distress and suicide. The mental health burden associated with a diagnosis and treatment is substantial, pointed out Zachary Klaassen, MD, of the Georgia Cancer Center at […]