Fracture Risk Bumped With Testosterone Therapy in Hypogonadal Men
Testosterone treatment didn’t offer protection against fractures in men with hypogonadism, a TRAVERSE subtrial indicated. Compared with placebo, men who were on a testosterone gel actually had a significantly higher risk for fracture (HR 1.43, 95% CI 1.04-1.97), found Peter Snyder, MD, of the University of Pennsylvania in Philadelphia, and colleagues. During the median 3.19-year […]
Study Assuages Fears of Pancreatic Cancer Risk With GLP-1 Receptor Agonists
Several years after initiating treatment, GLP-1 receptor agonist users didn’t have a pancreatic cancer safety signal, a historical cohort study reported. Compared with basal insulin users, those on a GLP-1 receptor agonist didn’t have a significantly different risk for developing pancreatic cancer in the 5 to 7 years that followed (HR 0.50, 95% CI 0.15-1.71), […]
Testosterone for Hypogonadism Cleared So Far of Prostate Cancer Risk
Men treated with testosterone replacement therapy (TRT) for hypogonadism didn’t have an increase in adverse prostate events, the TRAVERSE trial found. Over a mean follow-up of 33 months, those who used topical 1.62% testosterone gel had a 0.19% incidence of high-grade prostate cancer (Gleason score ≥4 + 3), similar to the 0.12% among placebo-treated men […]
COVID Cleared of Increasing Risk of Type 1 Diabetes in Kids?
COVID-19 infection didn’t appear to precipitate a diagnosis of type 1 diabetes in kids, a prospective multinational cohort study suggested. Researchers tested more than 4,500 adolescents every few months for type 1 diabetes, SARS-CoV-2 infection, and vaccination antibodies from January 2020 through December 2021. However, there was no difference among the 45 kids diagnosed with […]
Pre-COPD Current and Former Smokers Not in the Clear for Airway Disease
Whether they had respiratory symptoms or not, former and current smokers who didn’t meet criteria for chronic obstructive pulmonary disease (COPD) had similar declines in lung function and progression to COPD in subsequent years, the SPIROMICS II study found. Participants with symptomatic tobacco exposure and preserved spirometry (TEPS) experienced no significant difference in annual declines […]
AKI Cleared of Worsening CKD Trajectory
Acute kidney injury (AKI) didn’t predict worsening kidney function in people with chronic kidney disease (CKD), a prospective study showed. According to findings from the Chronic Renal Insufficiency Cohort (CRIC) study, CKD patients hospitalized for AKI saw a statistically insignificant drop in estimated glomerular filtration rate (eGFR) during a nearly 4-year follow-up period, reported Chi-yuan […]
Shorter Antibiotic Course Not as Effective for Children With UTIs
Abbreviated antibiotic treatment didn’t measure up for children with urinary tract infection (UTI), the SCOUT trial found. Stopping antibiotics when symptoms improved after an initial 5-day course yielded a 4.1% rate of persistent symptomatic UTI by follow-up at day 11-14 compared with 0.6% when kids had the full 10-day course, Nader Shaikh, MD, MPH, of […]
When My Relationship Started To Feel Like An Addiction, We Went Cold Turkey For 30 Days
“I didn’t want to break up, but I decided this was the way to reset from the abnormal — albeit fun — infatuation and give us some space to reflect on whether we were actually a good match,” the author writes. Abdullah Durmaz via Getty Images You know the feeling when you’re really falling for […]
For Septic Shock, Another Toss-up Between Emphasizing Vasopressors Vs Fluids
SAN FRANCISCO — For sepsis-induced hypotension, a restrictive fluid strategy with earlier vasopressor use didn’t impact mortality compared with liberal fluids, the CLOVERS trial showed. The restrictive strategy had its intended effect, reducing median IV fluids administered over 24 hours by 2,134 mL in favor of more vasopressor use compared with the liberal fluids strategy […]
Autopsies Show COVID-19 in the Brain
Early this year, leading researchers discussed what we knew — and didn’t know — about COVID-19 and the brain. Since then, new findings have emerged about SARS-CoV-2 and the nervous system, including the results of an autopsy study that showed the presence of the virus throughout the body and brain. How can a respiratory pathogen […]