Steroid Fails to Boost Survival in Advanced HIV Patients With TB Meningitis
Adding dexamethasone to treatment for tuberculous (TB) meningitis among heavily immunosuppressed HIV-positive patients in a low-resource setting did not significantly improve survival or confer any other measured benefits, a randomized controlled trial showed. Among 520 HIV-positive adults in Vietnam and Indonesia who received a year of chemotherapy for TB meningitis, 44.1% of those who also […]
Dexamethasone or Surgery for Chronic Subdural Hematoma?
Dexamethasone treatment failed to demonstrate noninferiority to surgery for chronic subdural hematoma and was associated with more complications and a greater risk of later surgery, according to results of a randomized study terminated early due to safety and outcome concerns. In the DECSA trial, the odds ratio of a better functional outcome score with dexamethasone […]
Why drug used to treat critically ill COVID-19 patients may only benefit males: Research into the way our immune systems respond to COVID-19 reveals the sex of a patient may affect how well drugs work
A new study from the University of Calgary shows how dexamethasone, the main treatment for severe COVID-19 lung infections, alters how immune cells work, which may help male patients, but has little to no benefit for females. These remarkable findings are the result of a multidisciplinary study published in Nature Medicine, led by Dr. Jeff […]