Two-Stage Screening Strategy for Ovarian Cancer Continues to Show Progress
A two-stage ovarian cancer screening strategy substantially improved early-stage detection among average-risk postmenopausal women, according to long-term follow-up from a large prospective study. Combining serial CA125 values and conditional referral for transvaginal sonography (TVS) led to a sensitivity of 74% for detection of ovarian and borderline cancers. Cancers detected by the Risk of Ovarian Cancer […]
AI-Aided Colonoscopy Flops for Advanced Neoplasia Detection in Trial
Incorporating artificial intelligence (AI) computer-aided detection systems (CADe) into colonoscopy does not improve rates of advanced neoplasia detection, according to two studies in Annals of Internal Medicine. In the randomized CADILLAC trial of patients with a positive fecal immunochemical test, detection of advanced colorectal neoplasia was virtually identical with or without the use of CADe […]
AI-Backed Mammography Keeps Up With Docs for Cancer Detection
Artificial intelligence-supported mammography resulted in a cancer detection rate comparable to that of two breast radiologists working together, while also substantially cutting screening workload. Among more than 80,000 women randomized to either AI-supported mammography screening or to standard double reading without AI, cancer detection rates were 6.1 (95% CI 5.4-6.9) per 1,000 screened participants in […]
Are Skin Lesion Analyzers Ready for Prime Time?
While the FDA is proposing to reclassify two class III computer-aided melanoma detection devices as class II devices, most members of its General and Plastic Surgery Devices Panel suggested that such a move would be premature during the Medical Devices Advisory Committee meeting on Friday. According to the FDA, reclassification of the MelaFind and Nevisense […]
New smartphone clip-on can detect Zika virus in blood samples
As seen with the COVID-19 pandemic, detection methods that are rapid, simple, accurate, and sensitive are vital for detecting viral pathogens and for controlling the spread of infectious diseases. Unfortunately, laboratory-based methods often require trained personnel and involve complex procedures. In a new study, researchers at the University of Illinois Urbana-Champaign have combined their efforts […]
Serrated Polyp Detection a Good Indicator of Colonoscopy Quality
While the adenoma detection rate (ADR) is a well-established quality indicator for colonoscopy, the proximal serrated polyp detection rate (PSPDR) should be used as a complementary tool, according to a Dutch population-based study. Among over 200,000 colonoscopies performed by 441 endoscopists, each percentage point increase in the PSPDR was associated with a 7% lower risk […]
A Closer Look at the Monkeypox Outbreak’s Less Than Typical Symptoms
Considering monkeypox in the differential diagnosis is important for early detection and curbing transmission, according to researchers of an observational analysis from England. Among 54 men who have sex with men (MSM) who were diagnosed with monkeypox, all presented with skin lesions, 94% of which were anogenital, while 67% reported fatigue or lethargy and 57% […]
Number of U.S. Cancer Survivors Grows to 18 Million
A growing — and aging — population, combined with advances in early detection and treatment, pushed the number of cancer survivors to new heights this year. More than 18 million Americans with a history of cancer, two-thirds of them over the age of 65 years, were living in the U.S. as of January 1 of […]
Fluorescence-Guided Lumpectomy Shows Promise
A fluorescence-guided imaging system could improve intraoperative detection of residual breast cancer in women undergoing lumpectomy, a prospective single-arm study suggested. The system, which incorporates the activatable fluorescent imaging agent pegulicianine (LUM015) had higher sensitivity, though lower specificity, than standard pathology review of the main lumpectomy specimen, reported Shelley Hwang, MD, MPH, of Duke University […]
PSMA PET Plus MRI Better Detects Clinically Significant Prostate Cancers
MRI combined with prostate-specific membrane antigen (PSMA) PET improved the detection of clinically significant prostate cancer compared with MRI alone, and can potentially allow for a reduction in the number of biopsies needed for diagnosis, according to results from the PRIMARY trial. The combined approach demonstrated an increase in negative predictive value for detecting prostate […]