‘Potential Detrimental Effect’ With Fourth-Line Olaparib in Ovarian Cancer
NEW YORK — A post-hoc analysis of overall survival (OS) in the SOLO3 trial demonstrated why olaparib (Lynparza) recently had its fourth-line indication in ovarian cancer pulled by drugmaker AstraZeneca. The phase III trial, which tested olaparib versus non-platinum chemotherapy for women with BRCA-mutated platinum-sensitive relapsed disease, found diverging OS signals based on whether women […]
Intriguing connection between diet, eye health and lifespan uncovered
Researchers from the Buck Institute have demonstrated for the first time a link between diet, circadian rhythms, eye health and lifespan in Drosophila. Publishing in the June 7, 2022 issue of Nature Communications, they additionally and unexpectedly found that processes in the fly eye are actually driving the aging process. Previous studies have shown in […]
Intratumoral Combo Shrinks Melanomas Refractory to Anti-PD-1
Intratumoral injection of an investigational agent, BO-112, combined with pembrolizumab (Keytruda) demonstrated promising efficacy in certain patients with advanced melanoma refractory to anti-PD-1-based therapy, according to results from a single-arm phase II trial. Ten of 40 evaluable patients responded to treatment — six partial and four complete responses — meeting the study’s primary endpoint of […]
Exercise during pregnancy reduces the risk of Type-2 Diabetes in offspring
A new study has demonstrated that maternal exercise during pregnancy improves the metabolic health of offspring, even when the mother is obese or on a high-fat diet. Physical exercise by the mother induces the placenta to secrete the key protein SOD3, resulting in a lowered risk of diabetes for the offspring. The findings in the […]
Eye imaging technology breaks through skin by crossing beams: New approach to optical coherence tomography increases its depth of view in biological tissues
Biomedical engineers at Duke University have demonstrated a method for increasing the depth at which optical coherence tomography (OCT) can image structures beneath skin. The gold standard for imaging and diagnosing diseases within the retina, OCT has yet to find widespread use as an imaging technique for other parts of the body due to its […]
Tens Of Thousands Protest Belgium’s Tighter COVID-19 Rules Amid Spike
BRUSSELS (AP) — Ten of thousands of people demonstrated through central Brussels on Sunday to protest reinforced COVID-19 restrictions imposed by the Belgian government to counter the latest spike in coronavirus cases. Many among the police estimate of 35,000 at the rally had already left for home when the demonstration descended into violence as several […]
Preterm Birth, Autism Link Cemented
Forty-plus years of Swedish birth and health data demonstrated a strong relationship between premature delivery and autism risk, according to a new analysis. Among more than 4 million singleton births from 1973 to 2013, the risk for diagnosis of autism spectrum disorder (ASD) was 2.1% for children born prior to 37 weeks’ gestation compared with […]
Comprehensive clinical sequencing opens door to the promise of precision medicine
St. Jude Children’s Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine. Results from the St. Jude Genomes for Kids study appear online today in the journal Cancer Discovery. Whole genome and whole exome sequencing of germline […]
Role of dopamine in songbird’s brain plasticity: Neurotransmitter shown to be a key driver in sensory processing
Neuroscientists at the University of Massachusetts Amherst have demonstrated in new research that dopamine plays a key role in how songbirds learn complex new sounds. Published in the Journal of Neuroscience, the finding that dopamine drives plasticity in the auditory pallium of zebra finches lays new groundwork for advancing the understanding of the functions of […]