Dexamethasone or Surgery for Chronic Subdural Hematoma?
Dexamethasone treatment failed to demonstrate noninferiority to surgery for chronic subdural hematoma and was associated with more complications and a greater risk of later surgery, according to results of a randomized study terminated early due to safety and outcome concerns. In the DECSA trial, the odds ratio of a better functional outcome score with dexamethasone […]
ICI/TKI Combo Maintains Survival Benefit in Advanced RCC
SAN FRANCISCO — First-line nivolumab (Opdivo) plus cabozantinib (Cabometyx) continued to demonstrate clinically meaningful survival benefits in advanced renal cell carcinoma (RCC). An update of the CheckMate 9ER trial, which compared the immune checkpoint inhibitor/tyrosine kinase inhibitor (TKI) doublet with the TKI sunitinib (Sutent), showed that after 44 months of median follow-up, median progression-free survival […]
Mindfulness therapy reduces opioid misuse and chronic pain in primary care, according to new research
Results from a new clinical trial demonstrate that an eight-week mindfulness-based therapy — Mindfulness-Oriented Recovery Enhancement (MORE) — decreased opioid use and misuse while reducing chronic pain symptoms, with effects lasting as long as nine months. This is the first large-scale clinical trial to demonstrate that a psychological intervention can simultaneously reduce opioid misuse and […]
BPA exposure of the placenta could affect fetal brain development
In a new study, scientists at the University of Missouri demonstrate the direct transmission of bisphenol A (BPA) from a mother to her developing child via the placenta could negatively impact fetal brain development. Cheryl Rosenfeld, a professor of biomedical sciences in the College of Veterinary Medicine, and colleagues propose more attention should be placed […]