Biden Says He’s ‘Feeling Good’ in First Remarks After Cancer Diagnosis Announced
NEW CASTLE — Former President Joe Biden delivered the first remarks since he announced he had an aggressive form of prostate cancer Friday, speaking in a steady voice during a somber Memorial Day gathering and later smiling and saying he’s “feeling good.” Biden spoke at an annual gathering marking Memorial Day at Veterans Memorial Park […]
Spinal Delivery of Gene Therapy Promising for Neurodegenerative Disease
Gene therapy delivered for the first time via lumbar puncture showed promise of benefit in slowing progression of giant axonal neuropathy (GAN) in a phase I clinical trial. The slope of change in motor function went from -7.17 percentage points per year before treatment to -0.54 percentage points with the lowest dose to an improvement […]
Oncolytic Virus Shows High Response Rates in BCG-Unresponsive Bladder Cancer
WASHINGTON — Treatment with cretostimogene grenadenorepvec, an investigational intravesically delivered oncolytic immunotherapy, achieved high response rates in patients with high-risk non-muscle-invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guérin (BCG), according to an interim analysis of the phase III BOND-003 trial. Among 66 patients evaluable for efficacy, 75.7% (95% CI 63-85) achieved a complete response (CR) […]
Opinion | ‘Bad News Is Bad News No Matter How It Is Delivered’: What We Heard This Week
“Bad news is bad news no matter how it is delivered.” — S. Trent Rosenbloom, MD, of Vanderbilt University in Nashville, Tennessee, commenting on whether patients prefer to receive test results immediately, even in the case of an abnormal one. “The first step is admitting you have a problem.” — Rep. Morgan Griffith (R-Va.), chair […]
Want a Few Weeks of Knee Pain Relief? Try This
PHILADELPHIA — Blocking agents delivered to genicular nerves around the knee markedly reduced osteoarthritis patients’ perceptions of pain, far more than those receiving placebo injections, a randomized trial showed. At week 4 following the injections, patients in the nerve block group reported mean reductions in pain scores of 3.0 points from baseline on a standard […]
Monoclonal Antibody Shows Protection Against Malaria
SEATTLE — A monoclonal antibody delivered intravenously was effective in protecting against Plasmodium falciparum infection over a 6-month malaria season in Mali, a phase II placebo-controlled trial showed. Among 330 healthy adults, P. falciparum infection was detected in 35.5% who received a single dose of CIS43LS 10 mg/kg, 18.2% who received a 40-mg/kg dose, and […]
FDA OKs Tdap Vaccine for Whooping Cough Protection Before Birth
The FDA announced approval of the first vaccine to be delivered through a pregnant mother to unborn babies for protection in the first 2 months of life. The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine Boostrix is to be given during the third trimester of pregnancy to deliver antibodies to the developing […]
Third U.S. Case of Congenital Varicella in the Last 25 Years
An Illinois mother with no history of varicella vaccination or documented disease delivered a premature infant with congenital varicella infection — reportedly only the third U.S. case of congenital varicella syndrome since 1995. The infant was born at 24 weeks gestation following induction of labor after ultrasound showed fetal abnormalities. The baby died shortly after […]
Morning exposure to deep red light improves declining eyesight
Just three minutes of exposure to deep red light once a week, when delivered in the morning, can significantly improve declining eyesight, finds a pioneering new study by UCL researchers. Published in Scientific Reports, the study builds on the team’s previous work*, which showed daily three-minute exposure to longwave deep red light ‘switched on’ energy […]