COX-2 Inhibitor Added to Levonorgestrel Improved Emergency Contraception Efficacy
Taking the oral cyclo-oxygenase (COX)-2 inhibitor piroxicam in combination with levonorgestrel improved emergency contraception efficacy versus levonorgestrel alone, with no additional adverse events, a randomized controlled trial showed. Piroxicam 40 mg combined with levonorgestrel 1.5 mg prevented 94.7% of expected pregnancies compared with 63.4% with levonorgestrel plus placebo (P<0.0001), reported Raymond Hang Wun Li, MD, […]
Drug Combination Promising as Pre-Sex Birth Control
A drug combination that uses emergency contraception and a cyclo-oxygenase-2 (COX-2) inhibitor may effectively disrupt ovulation, making it the first potential candidate for on-demand, pericoital oral contraception, according to an exploratory pilot study. Among a group of nine patients, six demonstrated ovulation disruption after taking a combination drug of ulipristal acetate (UA) and meloxicam, reported […]