Novel Regimens Yield High Response Rates for Older, Hodgkin Lymphoma Patients
Older patients with classical Hodgkin lymphoma unsuitable for conventional chemotherapy had high rates of durable responses with two brentuximab vedotin (BV; Adcetris) regimens, one that omitted chemotherapy, a small prospective study showed. Brentuximab plus the alkylating agent dacarbazine (DTIC) produced an objective response rate (ORR) of 95% in 22 patients, whereas brentuximab plus nivolumab (Opdivo) […]
SBRT Noninferior to Conventional RT for Intermediate-Risk Prostate Cancer
SAN DIEGO — Stereotactic body radiation therapy (SBRT) was as effective as conventional radiation therapy (CRT) in treating intermediate-risk prostate cancer, according to results from the randomized PACE-B trial. Among 874 patients, those randomized to CRT had a biochemical/clinical failure-free rate of 94.6% versus 95.8% for those randomized to SBRT (HR 0.73, 90% CI 0.47-1.12, […]
Opinion | ‘Believe in Your Data and Question Conventional Wisdom’: What We Heard This Week
“Two lessons: believe in your data and question conventional wisdom.” — Stephen Hauser, MD, of the University of California San Francisco, discussing his book, The Face Laughs While the Brain Cries. “You don’t always think a chip can be dangerous.” — Scott Krakower, DO, of Northwell Health in New York, about the ‘One Chip Challenge’ […]
Case Builds Against Beta-Blockers Beyond First Year After Heart Attack
The conventional wisdom of giving long-term beta-blockers for secondary prevention after myocardial infarction (MI), in the absence of another clinical indication, was questioned by a large cohort study from Sweden. For survivors who were still on beta-blocker therapy 1 year after heart attack hospitalization and had a normal left ventricular (LV) ejection fraction, the next […]
Is it really healthy to restrict protein intake for kidney transplant recipients? Study suggests that sufficient protein intake is necessary to prevent sarcopenia after kidney transplantation
Conventional wisdom holds that low protein intake is essential for kidney disease patients. However, scientists from Osaka Metropolitan University demonstrated that it might not always be the case with their recent study on the relationship between protein intake and skeletal muscle mass in kidney transplant recipients. Their findings were published in Clinical Nutrition. Chronic kidney […]