More Data Support Olaparib-Abiraterone in BRCA-Mutant Prostate Cancer
Combining olaparib (Lynparza) with abiraterone acetate (Zytiga) as first-line therapy for biomarker-selected patients with metastatic castration-resistant prostate cancer significantly improved progression-free survival (PFS) versus either agent alone, according to findings from a small phase II trial presented at this year’s Genitourinary Cancers Symposium. In this exclusive MedPage Today video, Daniel Geynisman, MD, of Fox Chase […]
SBRT Added to Standard Tx Boosts Outcomes in Oligometastatic Prostate Cancer
Combining stereotactic body radiation therapy (SBRT) with standard systemic therapy yielded significant increases in the rates of biochemical response and progression-free survival (PFS) in patients with oligometastatic castrate-resistant prostate cancer (CRPC), the phase II randomized ARTO trial showed. In a cohort of 157 patients at 6 months after the start of treatment, biochemical response was […]
Enzalutamide-ADT Cuts Risk for Disease Spread in Nonmetastatic Prostate Cancer
CHICAGO — Combining enzalutamide (Xtandi) with an androgen deprivation therapy (ADT) boosted metastasis-free survival (MFS) in patients with prostate cancer at high risk for biochemical recurrence, according to the EMBARK trial. After a median follow up of 60.7 months, the combination of enzalutamide and leuprolide acetate ADT demonstrated a 58% reduction in the risk of […]
Taxane, Anthracycline Combo Most Effective in Reducing Breast Cancer Recurrence
Combining anthracycline and taxane for early-stage operable breast cancer was more effective than either anthracycline or taxane chemotherapy alone in reducing breast cancer recurrence and death, according to a meta-analysis. Moreover, regimens with higher cumulative doses of anthracycline plus taxane were associated with the greatest benefit, according to a report from Jeremy Braybrooke, BM, PhD, […]
Vitamin E can boost immunotherapy responses by reinvigorating dendritic cells
Combining a retrospective analysis of clinical records with in-depth laboratory studies, researchers at The University of Texas MD Anderson Cancer Center have discovered that vitamin E can enhance immunotherapy responses by stimulating the activity of dendritic cells in the tumor. The findings were published today in Cancer Discovery. The researchers demonstrated that vitamin E directly […]
Comprehensive RNA-Atlas: Researchers have built one of the most comprehensive catalogues of the human transcriptome ever
By cleverly combining complementary sequencing techniques, researchers have deepened our understanding of the function of known RNA molecules and discovered thousands of new RNAs. A better understanding of our transcriptome is essential to better understand disease processes and uncover novel genes that may serve as therapeutic targets or biomarkers. The article ‘The RNA Atlas expands […]
Synthetic tissue can repair hearts, muscles, and vocal cords
Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine. “People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand […]