Opinion | A Closer Look at the New Statin Therapy Guidelines for Patients With HIV
Fitch is a clinical research nurse practitioner. Diggs is a clinical research coordinator. Grinspoon is a professor of medicine and a clinical researcher. Ms. C*, a 53-year-old African American woman living with HIV for almost a decade, inquired about the recently released recommendations for cardiovascular disease prevention among people with HIV (PWH). Her predicted 10-year […]
Opinion | A Closer Look at the New Statin Therapy Guidelines for Patients With HIV
Fitch is a clinical research nurse practitioner. Diggs is a clinical research coordinator. Grinspoon is a professor of medicine and a clinical researcher. Ms. C*, a 53-year-old African American woman living with HIV for almost a decade, inquired about the recently released recommendations for cardiovascular disease prevention among people with HIV (PWH). Her predicted 10-year […]
New Tuberculosis Framework May Improve Research, Clinical Care
A new framework may better characterize the early stages of tuberculosis (TB) and improve research and clinical care, an international team of researchers said. Turning against the current “active” or “latent” classification of TB, the International Consensus for Early TB (ICE-TB) group released a five-state system that distinguishes disease from infection, clinical versus subclinical states, […]
Havana Syndrome Mystery Continues to Deepen
Despite persistent symptoms, no significant evidence of brain injury and no abnormalities in most clinical measures were found in U.S. government personnel who experienced anomalous health incidents (AHIs) known as Havana syndrome, NIH researchers said. After adjusting for multiple comparisons, no differences in MRI measures of brain structure or function emerged between individuals with AHIs […]
Can Medical Decision-Making Keep Up With the Science?
On average, it takes 17 years for new treatments to reach mainstream clinical practice. That means that when patients see a doctor in 2020, they are often getting guidance from 2003. To put this into perspective, current practices come from a time before the iPhone! But during the pandemic, the speed of changes to medical […]
Ozanimod Controls MS Disease Activity Regardless of Age
WEST PALM BEACH, Fla. — Clinical and radiologic measures of disease activity remained stable or improved for relapsing multiple sclerosis (RMS) patients in all age groups over 7 to 8 years of continuous treatment with ozanimod (Zeposia). “Regardless of age category, the adjusted annualized relapse rate was below 0.2 in the phase III parent trials […]
Opinion | What Does AI Say About the Claims on Ivermectin for COVID?
Teres is a critical care physician and clinical instructor in public health and community medicine. Oppenlander is an associate professor of statistics and bioethics. Strosberg is a professor of healthcare policy and bioethics. Science is like baseball. To score a run — to convincingly show that a drug or intervention is safe and effective — […]
Add-On Clarithromycin Pans Out in Community-Acquired Pneumonia Trial
In a phase III trial, the addition of oral clarithromycin to beta-lactam antibiotic treatment improved the clinical response of people with community-acquired pneumonia who had systemic inflammatory response syndrome, findings that support existing guidelines. In the study, the proportion of patients meeting the primary composite endpoint after 72 hours of treatment — fulfilling criteria for […]
No Improved Outcomes for HF Patients With Sleep Apnea Using ASV Breathing Devices
Breathing machines with adaptive servo-ventilation (ASV) did not improve survival or other clinical outcomes in patients with heart failure (HF) and reduced ejection fraction and sleep-disordered breathing, the phase III ADVENT-HF trial found. Investigators found no difference between patients randomized to standard care plus bilevel positive airway pressure (BiPAP) device therapy with ASV and those […]
Clinical Challenges: Test Your Knowledge of Breast Cancer
A MedPage Today Clinical Challenges series on breast cancer reviewed locoregional therapy for older patients, the management of invasive lobular cancer (ILC), and the treatment of advanced hormone receptor (HR)-positive disease post-CDK4/6 inhibition. The following is a three-question quiz to test your knowledge on each aspect of the series. Correct answers and explanations appear after […]