Opening Blood-Brain Barrier to Deliver Alzheimer’s Drug Shows Promise
Aducanumab (Aduhelm) infusions combined with focused ultrasound led to lower cerebral amyloid-beta levels in Alzheimer’s disease, a proof-of-concept trial showed. The investigational treatment involved creating an opening in the blood-brain barrier with MRI-guided focused ultrasound to boost drug delivery. In each of three participants who received aducanumab infusions, amyloid reduction was greater in brain regions […]
Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven
BOSTON — Cerebral embolic protection (CEP) again came up empty in preventing strokes after transcatheter aortic valve replacement (TAVR) despite safely capturing embolic material dislodged during the procedure, a large randomized trial found. In the 3,000-person PROTECTED TAVR trial, the sentinel dual-filter system produced no significant reduction in periprocedural strokes compared with control cases without […]