Another Possible Option for HER2-Mutated Non-Small Cell Lung Cancer
More than half of patients with treatment-refractory HER2-positive non-small cell lung cancer (NSCLC) responded to an anti-HER2 antibody-drug conjugate, data from a preliminary trial showed. Fifty of 91 patients responded to trastuzumab deruxtecan (T-DXd) and another 34 patients had stable disease, resulting in a disease control rate exceeding 90%. Responses were durable in many cases, […]
Immuno-Oncology Combo Active in Recurrent EGFR/ALK Positive NSCLC
Patients with recurrent EGFR/ALK-positive non-small cell lung cancer (NSCLC) obtained durable remissions with the combination of pembrolizumab (Keytruda) and chemotherapy, a small prospective study showed. The immuno-oncology (IO) combination led to a median progression-free survival (PFS) of 8.3 months in EGFR-mutant NSCLC and overall survival (OS) of 22.2 months. The combination had limited activity in […]
Sensor spies hideouts for ?virus replication: An antiviral, found in some people’s cells, outwits an immune escape plan used by several dangerous viruses
While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a “detective enzyme” might be attuned to their whereabouts. A slight variation in their genomic code gives some people’s cells the capacity to produce this sensor. Many positive-strand RNA viruses share a strategy to avoid detection by […]
‘Frameshifting’ therapy for mast cell cancers reduces size, spread
A potential new treatment for mast cell cancers reduces the number of mast cells by “mutating” the messenger RNA (mRNA) before it can deliver instructions for manufacturing the gene responsible for cell proliferation. The method, known as frameshifting, changes the pre-mRNA so that the mature mRNA is degraded and any protein produced from its instructions […]
Researcher creates cell lines to help treat mitochondrial diseases in children
The mitochondrion has garnered quite the reputation for its role as the “powerhouse of the cell.” These tiny, but mighty organelles play various life-sustaining roles, from powering our own cells and organs to fueling chemical and biological processes. But when they aren’t working properly, a number of rare diseases can occur. Mitochondrial diseases are a […]
Roadmap to HIV eradication via stem cell therapy: Study uncovers stem cells’ ability to restore immunity and repair gut damage caused by HIV
In a groundbreaking study, a team of UC Davis researchers has discovered a special type of stem cell that can reduce the amount of the virus causing AIDS, boosting the body’s antiviral immunity and repairing and restoring the gut’s lymphoid follicles damaged by the simian immunodeficiency virus (SIV), the equivalent of the human immunodeficiency virus […]