Opinion | It’s Time for a Risk-Adapted Approach to Breast Cancer Screening
Breast cancer is the second leading cause of cancer death in women in the U.S., and there is a substantial disparity in breast cancer mortality by race, particularly for early-onset breast cancer in Black women. In a recent study I co-authored and published in JAMA Network Open, we showed that if breast cancer screening is […]
Personalized Cancer Vaccine Boosts Recurrence-Free Survival in Melanoma
ORLANDO — Adding a personalized cancer vaccine to anti-PD-1 immunotherapy for resectable melanoma led to a 44% improvement in recurrence-free survival (RFS) versus immunotherapy alone, according to a study reported here. Patients who received the mRNA vaccine, derived from their own tumor, had an 18-month RFS of 78.6% as compared with 62.2% for patients who […]
Taxane, Anthracycline Combo Most Effective in Reducing Breast Cancer Recurrence
Combining anthracycline and taxane for early-stage operable breast cancer was more effective than either anthracycline or taxane chemotherapy alone in reducing breast cancer recurrence and death, according to a meta-analysis. Moreover, regimens with higher cumulative doses of anthracycline plus taxane were associated with the greatest benefit, according to a report from Jeremy Braybrooke, BM, PhD, […]
Bariatric Surgery May Eliminate Obesity-Related Breast Cancer Risk
Bariatric surgery for women with obesity was associated with a reduction in breast cancer risk that reached levels seen among those with a normal body mass index (BMI), researchers have found. In their retrospective study of almost 70,000 women, an increased risk for incident breast cancer was observed in women who did not undergo bariatric […]
Older Men Still Overscreened for Prostate Cancer, Survey Says
Older men are being overscreened for prostate cancer, despite U.S. Preventive Services Task Force (USPSTF) guidelines against prostate-specific antigen (PSA) testing in men ages 70 and up, a survey study showed. Among a cohort of over 30,000 men, recent PSA screening rates were 55.3% for men ages 70 to 74, 52.1% for those ages 75 […]
Leading Causes of Death Hit Childhood Cancer Survivors Earlier
Survivors of childhood cancer had a fourfold higher risk of mortality decades after their diagnosis, typically from the same leading causes of death afflicting the general U.S. population, a report from the Childhood Cancer Survivor Study (CCSS) showed. The 40-year all-cause mortality rate was 23.3% among the more than 34,000 pediatric cancer patients who had […]
CDK4/6 Inhibition Active in Recurrent Low-Grade Serous Ovarian Cancer
TAMPA, Fla. — About a fourth of patients with recurrent low-grade serous ovarian cancer (LGSOC) obtained durable responses to the combination of CDK4/6 inhibitor ribociclib (Kisqali) and letrozole, a small single-arm trial showed. Overall, 23% of 48 patients had partial responses, increasing to 26% in those who had baseline and confirmatory CT scans. Almost 80% […]
KRAS Mutations in Metastatic CRC Predict Survival Benefit of Chemo Combo
Codon-specific KRAS mutations are predictive of an overall survival (OS) benefit for metastatic colorectal cancer (mCRC) patients treated with trifluridine-tipiracil (FTD/TPI; Lonsurf), according to a genomics-based analysis. After identifying biomarkers of resistance and validating the findings in a real-world dataset, researchers showed that patients with KRAS G12-mutant tumors in the phase III RECOURSE trial achieved […]
Antibody-Drug Conjugates Take Breast Cancer Field by Storm
Antibody-drug conjugates (ADCs) have taken the field of breast cancer by storm and appear poised to expand their reach into earlier lines of therapy and early-stage disease, a breast cancer specialist said here. ADCs offer an “exciting and effective drug delivery system” for multiple subtypes of metastatic breast cancer, and ongoing clinical trials are exploring […]
Use of Active Surveillance in Prostate Cancer on the Rise, but Highly Variable
While use of active surveillance for the management of low-risk prostate cancer has increased in the U.S., it still varies widely both at the practitioner level and even within urology practices, according to a cohort study. Looking at over 20,000 patients included in a quality reporting registry, the rate of active surveillance increased “sharply and […]