Trastuzumab Deruxtecan Ushers in New Treatment Era for HER2-Low Breast Cancer
CHICAGO — Patients with HER2-low metastatic breast cancer treated with trastuzumab deruxtecan (Enhertu) achieved significant improvements in survival compared with those treated with chemotherapy alone, according to results from the DESTINY-Breast04 Trial. In the phase III international study, among a population of 494 patients with both HR-positive disease (88.7%) and HR-negative disease (11.3%), the risk […]
Promising rectal cancer study
UNC Lineberger Comprehensive Cancer Center’s Hanna K. Sanoff, MD, MPH, is the author of a viewpoint in the New England Journal of Medicine that provides a perspective on the evolving treatment of rectal cancer. She offers prospects for future treatment of the disease in light of encouraging findings from a study published in the journal […]
IL-15 Agonist Impresses in Non-Muscle Invasive Bladder Cancer
CHICAGO — Patients with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) had a high response rate and 2-year cancer-specific survival with an immunostimulatory fusion protein complex plus BCG, a prospective study showed. The intravesical combination led to complete responses in 71% of patients with carcinoma in situ (CIS), with a median response duration exceeding 2 years. […]
Targeted drug achieves 43% response rate in KRAS-mutated lung cancer: Experimental drug adagrasib also shows activity in lung cancer metastases to the brain
Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators. Mutations […]
Decoding the language of immune responses: Research has implications for improved immunotherapy treatments
Researchers from McGill University and the US National Cancer Institute (NCI) have made some surprising discoveries about our immune system. By using mathematical modelling to look at specific aspects of immune responses in mice and humans, their data-driven approach, described in a recent article in Science, reveals that immune responses may exist on a finer […]
High fat diet, unregulated athletic exercise endurance enhancers linked to risk of pancreatic cancer
Researchers at the University of Michigan Rogel Cancer Center have found a cell nuclear receptor activated by high fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of precancerous pancreas lesions into pancreatic cancer. Pancreatic ductal adenocarcinoma is a highly lethal form of cancer with rising occurrence, and strategies to prevent […]
Increased Public Assistance Tied to Better Cancer Survival in Black Patients
CHICAGO — Overall survival (OS) in Black patients with cancer improved significantly, and racial disparities in cancer survival decreased, with increased state-level spending on public welfare programs, a large retrospective review showed. Every 10% increase in public welfare spending was associated with an 8.6% improvement in cancer survival among Black patients, almost four times greater […]
The paired perils of breast cancer and diabetes
Breast cancer and type 2 diabetes would seem to be distinctly different diseases, with commonality only in their commonality. Breast cancer is the second most diagnosed malignancy after some types of skin cancer; approximately 1 in eight U.S. women will develop invasive breast cancer over the course of their lifetime. More than 10 percent of […]
Ultrasound-guided microbubbles boost immunotherapy efficacy: New platform to improve both antitumor immune responses and responses to checkpoint inhibitors
Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade. The findings from the preclinical study were published today in Nature Nanotechnology. As the first-of-its-kind platform, the Microbubble-assisted UltraSound-guided Immunotherapy of Cancer (MUSIC) approach […]
Obamacare Helped Extend Lives of People With Cancer
Latest Cancer News THURSDAY, May 19, 2022 (HealthDay News) Cancer survival rates rose more in states that expanded Medicaid under Obamacare than in those that did not, and rates increased most among Black patients and those in rural areas, according to a new study. “Our findings provide further evidence of the importance of expanding Medicaid […]