Alzheimer’s Biomarkers Common in People With Other Dementias
Alzheimer’s pathology was common in other dementias. An Alzheimer’s biomarker profile was seen in unspecified dementia, Parkinson’s dementia, and frontotemporal dementia. Biomarkers indicating Alzheimer’s-like pathology were tied to cognitive function. Alzheimer’s disease pathology was common in people diagnosed with other dementias, a large cross-sectional study in Sweden showed. While most patients clinically diagnosed with Alzheimer’s […]
Post-COVID Cognitive Deficits Linked With Clotting Proteins
Two distinct blood biomarker profiles predicted cognitive deficits 6 and 12 months after COVID-19, prospective U.K. data showed. Both biomarker profiles featured proteins involved in coagulation, reported Maxime Taquet, PhD, of the University of Oxford in England, and co-authors in Nature Medicine. Among 1,800 patients hospitalized for COVID-19 during the first wave of the pandemic, […]
FDA Panel Supports Tofersen for Rare Genetic ALS
A panel of FDA advisors voted unanimously that plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, is a reasonable surrogate endpoint in amyotrophic lateral sclerosis (ALS) associated with a mutation in the SOD1 gene (SOD1-ALS). In a 9-0 vote on Wednesday, the agency’s Peripheral and Central Nervous System Drugs Advisory Committee said the available […]
Presepsin a ‘Robust’ Biomarker of Early-Onset Sepsis
Presepsin holds promise as a biomarker for early-onset sepsis (EOS), a systematic review and meta-analysis confirmed. Across a dozen clinical trials, presepsin had a pooled sensitivity of 0.93 for the primary analysis of culture-proven sepsis (95% CI 0.86-0.96), a pooled specificity of 0.91 (95% CI 0.85-0.95), and a pooled diagnostic odds ratio (DOR) of 131.7 […]