Novel Antibiotic Combo Bests Meropenem for Complicated UTIs
Cefepime-taniborbactam, an investigational beta-lactam and beta-lactamase inhibitor combination, was superior to meropenem for the treatment of hospitalized patients with complicated urinary tract infection (UTI), including acute pyelonephritis, a phase III randomized study showed. In the microbiologic intention-to-treat (ITT) population, the composite microbiologic and clinical success rate with the combination at test-of-cure (trial days 19 to […]
Add-On Clarithromycin Pans Out in Community-Acquired Pneumonia Trial
In a phase III trial, the addition of oral clarithromycin to beta-lactam antibiotic treatment improved the clinical response of people with community-acquired pneumonia who had systemic inflammatory response syndrome, findings that support existing guidelines. In the study, the proportion of patients meeting the primary composite endpoint after 72 hours of treatment — fulfilling criteria for […]