Base-Edited CAR-T Product ‘Potent’ in Relapsed Childhood T-Cell ALL
The use of base editing to generate universal off-the-shelf chimeric antigen receptor (CAR) T cells in patients with relapsed T-cell acute lymphoblastic leukemia (ALL) should be further investigated based on promising interim results from a phase I study. In one of three patients — a 13-year-old girl who had relapsed T-cell ALL after allogeneic stem […]
Discovery could enable broad coronavirus vaccine
The COVID-causing virus SARS-CoV-2 harbors a vulnerable site at the base of its spike protein that is found also on closely related coronaviruses, according to a new study from Scripps Research. The discovery, published Feb 8 in Science Translational Medicine, could inform the design of broad-acting vaccines and antibody therapies capable of stopping future coronavirus […]