Probiotic Proves Its Might for Staph Decolonization
A Bacillus subtilis probiotic demonstrated the ability to wipe out most Staphylococcus aureus colonization without altering the gut microbiome, a placebo-controlled phase II study conducted in Thailand showed. Of 115 healthy individuals with natural S. aureus colonization, 30 days of the probiotic led to a 96.8% reduction in S. aureus in stool (P<0.0001) and a […]
FDA Approves First Gene Therapy for Non-Muscle-Invasive Bladder Cancer
The FDA has approved nadofaragene firadenovec (Adstiladrin) as the first gene therapy for the treatment of high-risk bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC), the agency announced on Friday. An adenoviral vector-based product, nadofaragene firadenovec, is specifically indicated for adult patients with carcinoma in situ (CIS) with or without papillary tumors. Approval was based on […]
Durable Responses With IL-15 Superagonist in Early Bladder Cancer
The use of the IL-15RAFC superagonist N-803 with intravesical bacillus Calmette-Guérin (BCG) resulted in high and more durable response rates in patients with non-muscle invasive bladder cancer (NMIBC) carcinoma in situ who were unresponsive to BCG, a phase II/III study found. Of the 81 patients included in the analysis, 58 achieved a complete response at […]